WorldCat Identities

Mersch-Sundermann, Volker 1953-

Overview
Works: 31 works in 42 publications in 3 languages and 243 library holdings
Genres: Handbooks and manuals 
Roles: Editor, Contributor, dgs, Author, Other
Classifications: RA770, 690.0286
Publication Timeline
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Most widely held works by Volker Mersch-Sundermann
Umweltmedizin Grundlagen der Umweltmedizin - klinische Umweltmedizin - ökologische Medizin ; 225 Tabellen( Book )

2 editions published in 1999 in German and held by 63 WorldCat member libraries worldwide

Handbuch Gebäude-Schadstoffe und gesunde Innenraumluft( Book )

2 editions published between 2012 and 2015 in German and held by 42 WorldCat member libraries worldwide

Beiträge zur Umweltmedizin( Book )

1 edition published in 1999 in German and held by 34 WorldCat member libraries worldwide

Medizinische Mikrobiologie für MTA( Book )

3 editions published in 1989 in German and held by 31 WorldCat member libraries worldwide

Untersuchungen zur Wirkung der Akupunktur auf Kraft und Schmerz bei Freizeitsportlern mit Achillessehnentendinose by Michaela Weiß( )

1 edition published in 2011 in German and held by 10 WorldCat member libraries worldwide

Untersuchung zur therapeutischen Wirksamkeit der Akupunkturtherapie bei Tendinosen der untern Extremität bei Sportlern by Katrin Spiess( )

1 edition published in 2011 in German and held by 10 WorldCat member libraries worldwide

Zusammenfassung: Achillessehnenbeschwerden nehmen durch die Verbreitung von Laufsportarten zu und können häufig nur unbefriedigend behandelt werden. Ziel unserer Untersuchungen war, ob sich mittels Akupunktur Achillessehnenbeschwerden subjektiv und objektiv beeinflussen lassen. 15 Freizeitsportler mit Achillessehnenbeschwerden (4 Frauen, 11 Männer, mittleres Alter 48,9 Jahre) wurden in die Akupunkturgruppe (A) eingeschlossen. Sie erhielten jeweils 12 halbstündige Akupunkturbehandlungen in einem Zeitraum von 8 Wochen. Jeweils vor Beginn und nach der 8 wöchigen Therapiephase wurden das Abrollverhalten des Fußes (plantare Kontaktzeit und Druckverteilung), die elektromyographisch gemessene neuromuskuläre Aktivierung der Unterschenkel-muskulatur, die subjektive Schmerzempfindung (Pain Dissability Index) und die algometrisch gemessenen Schmerzen, bestimmt
Antibiotics and sweeteners in the aquatic environment : biodegradability, formation of phototransformation products, and in vitro toxicity by Marlies Bergheim( )

2 editions published in 2015 in English and held by 4 WorldCat member libraries worldwide

Recalcitrant pharmaceuticals in the aquatic environment a comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity by Marlies Bergheim( )

2 editions published between 2014 and 2015 in English and held by 4 WorldCat member libraries worldwide

The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells by Evelyn- Lamy( )

2 editions published in 2013 in English and held by 3 WorldCat member libraries worldwide

Abstract: 4-methylthiobutyl isothiocyanate (MTBITC), an aliphatic, sulphuric compound from Brassica vegetables, possesses in vitro and in vivo antitumor activity. Recently we demonstrated the potent growth inhibitory potential of the DNA damaging agent MTBITC in human liver cancer cells. Here we now show that MTBITC down regulates telomerase which sensitizes cells to apoptosis induction. This is mediated by MAPK activation but independent from production of reactive oxygen species (ROS). Within one hour, MTBITC induced DNA damage in cancer cells correlating to a transient increase in hTERT mRNA expression which then turned into telomerase suppression, evident at mRNA as well as enzyme activity level. To clarify the role of MAPK for telomerase regulation, liver cancer cells were pre-treated with MAPK-specific inhibitors prior to MTBITC exposure. This clearly showed that transient elevation of hTERT mRNA expression was predominantly mediated by the MAPK family member JNK. In contrast, activated ERK1/2 and P38, but not JNK, signalled to telomerase abrogation and consequent apoptosis induction. DNA damage by MTBITC was also strongly abolished by MAPK inhibition. Oxidative stress, as analysed by DCF fluorescence assay, electron spin resonance spectroscopy and formation of 4-hydroxynonenal was found as not relevant for this process. Furthermore, N-acetylcysteine pre-treatment did not impact MTBITC-induced telomerase suppression or depolarization of the mitochondrial membrane potential as marker for apoptosis. Our data therefore imply that upon DNA damage by MTBITC, MAPK are essential for telomerase regulation and consequent growth impairment in liver tumor cells and this detail probably plays an important role in understanding the potential chemotherapeutic efficacy of ITC
Umweltmedizin : Grundlagen der Umweltmedizin, klinische Umweltmedizin, ökologische Medizin( Book )

1 edition published in 1999 in German and held by 3 WorldCat member libraries worldwide

Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status by Evelyn Lamy( )

2 editions published in 2013 in English and held by 3 WorldCat member libraries worldwide

Abstract: Isothiocyanates from plants of the order Brassicales are considered promising cancer chemotherapeutic phytochemicals. However, their selective cytotoxicity on liver cancer has been barely researched. Therefore, in the present study, we systematically studied the chemotherapeutic potency of 4-methylthiobutyl isothiocyanate (MTBITC). Selective toxicity was investigated by comparing its effect on liver cancer cells and their chemoresistant subpopulations to normal primary hepatocytes and liver tissue slices. Additionally, in a first assessment, the in vivo tolerability of MTBITC was investigated in mice. Growth arrest at G2/M and apoptosis induction was evident in all in vitro cancer models treated with MTBITC, including populations with cancer initiating characteristics. This was found independent from TP53; however cell death was delayed in p53 compromised cells as compared to wt-p53 cells which was probably due to differential BH3 only gene regulation i. e. Noxa and its antagonist A1. In normal hepatocytes, no apoptosis or necrosis could be detected after repeated administration of up to 50 µM MTBITC. In mice, orally applied MTBITC was well tolerated over 18 days of treatment for up to 50 mg/kg/day, the highest dose tested. In conclusion, we could show here that the killing effect of MTBITC has a definite selectivity for cancer cells over normal liver cells and its cytotoxicity even applies for chemoresistant cancer initiating cells. Our study could serve for a better understanding of the chemotherapeutic properties of isothiocyanates on human liver-derived cancer cells
Biochemical Interpretation of Quantitative Structure-Activity Relationships (QSAR) for Biodegradation of N-Heterocycles A Complementary Approach to Predict Biodegradability by Bodo Philipp( )

2 editions published between 2007 and 2008 in English and held by 3 WorldCat member libraries worldwide

The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumor model of HCC by Corinna Herz( )

2 editions published in 2014 in English and held by 3 WorldCat member libraries worldwide

Abstract: In contrast to cancer cells, most normal human cells have no or low telomerase levels which makes it an attractive target for anti-cancer drugs. The small molecule sulforaphane from broccoli is known for its cancer therapeutic potential in vitro and in vivo . In animals and humans it was found to be quickly metabolized into 4-methylthiobutyl isothiocyanate (MTBITC, erucin) which we recently identified as strong selective apoptosis inducer in hepatocellular carcinoma (HCC) cells. Here, we investigated the relevance of telomerase abrogation for cytotoxic efficacy of MTBITC against HCC.The drug was effective against telomerase, independent from TP53 and MTBITC also blocked telomerase in chemoresistant subpopulations. By using an orthotopic human liver cancer xenograft model, we give first evidence that MTBITC at 50 mg/KG b.w./d significantly decreased telomerase activity in vivo without affecting enzyme activity of adjacent normal tissue. Upon drug exposure, telomerase decrease was consistent with a dose- dependent switch to anti-survival, cell arrest and apoptosis in our in vitro C odels. Blocking telomerase by the specific inhibitor TMPyP4 further sensitized cancer cells to MTBITC-mediated cytotoxicity. Overexpression of hTERT, but not enzyme activity deficient DNhTERT, protected against apoptosis; neither DNA damage nor cytostasis induction by MTBITC was prevented by hTERT overexpression. These findings imply that telomerase enzyme activity does not protect against MTBITC-induced DNA damage but impacts signalling processes upstream of apoptosis execution le
Entwicklung neuartiger Expositionssysteme zur Untersuchung biologischer Wirkungen geringer Mengen nanoskaliger Partikel auf Filtersystemen sowie in humanen Lungenzellen an der Luft-Flüssigkeits-Grenzschicht by Sascha Simon Heilemann( )

1 edition published in 2016 in German and held by 2 WorldCat member libraries worldwide

Zusammenfassung: Humans are more and more exposed to nano-scaled materials because of the use and the man-made production of fine and ultrafine particles respectively. This applies especially to the exposition at workplaces (e.g. nanotechnology, metal industry, livestock breeding). In addition it also applies to the use of food and sanitary products (e.g. silver nano-particles, titanium dioxide) and to the exposition to polluted air (e.g. traffic, private heating units, industrial emissions).In order to be able to determine possible biological or rather toxic effects of these particles, a system is needed that can precisely aerosolize the smallest possible amounts of the partially expensive, and sometimes hard to obtain, particles (often nano-particles) and direct them onto the target system. Since smaller particles usually result in bigger health risks, this work focused on ultrafine as well as nano-scaled particles. These particles can intrude deeply into the lung, partially migrate into the blood and even overcome the blood-brain-barrier (Shah et al. 2015; EPA 2014).The objective of this research is the development of an aerosol generator for the smallest possible amounts of particles, on the one hand to load filters and on the other hand to expose cells
Management von Krankenhausinfektionen - Ressourcenverbrauch und Kosteneffektivität( )

1 edition published in 2011 in German and held by 2 WorldCat member libraries worldwide

Sensory irritations and pulmonary effects in human volunteers following short-term exposure to pinewood emissions by Richard Gminski( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Legionella-Pneumonien in Kliniken - Prävention und Infektionskontrolle wasserbürtiger Infektionen( )

1 edition published in 2011 in German and held by 2 WorldCat member libraries worldwide

 
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WorldCat IdentitiesRelated Identities
Alternative Names
Sundermann, Volker Mersch-.

Sundermann, Volker Mersch- 1953-

Languages
German (16)

English (13)

Polish (1)