WorldCat Identities

Karram, Khalad 1972-

Overview
Works: 6 works in 8 publications in 1 language and 39 library holdings
Roles: Author, Other, Contributor
Publication Timeline
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Most widely held works by Khalad Karram
Generation of a NG2-EYFP mouse for studying the properties of NG2-expressing cells by Khalad Karram( )

2 editions published in 2006 in English and held by 26 WorldCat member libraries worldwide

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier by Judith Hauptmann( )

2 editions published in 2020 in English and held by 5 WorldCat member libraries worldwide

Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. IL-1 signaling in BBB-ECs upregulated the expression of the adhesion molecules Vcam-1, Icam-1 and the chemokine receptor Darc, all of which have been previously shown to promote CNS-specific inflammation. In contrast, IL-1R1 signaling suppressed the expression of the stress-responsive heme catabolizing enzyme heme oxygenase-1 (HO-1) in BBB-ECs, promoting disease progression via a mechanism associated with deregulated expression of the IL-1-responsive genes Vcam1, Icam1 and Ackr1 (Darc). Mechanistically, our data emphasize a functional crosstalk of BBB-EC IL-1 signaling and HO-1, controlling the transcription of downstream proinflammatory genes promoting the pathogenesis of autoimmune neuroinflammation
Microglial A20 protects the brain form CD8-T cell mediated immunopathology by Alma Nazlie Mohebiany( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Regulation of IL-1 signaling by the decoy receptor IL-1R2 by Thomas Schlüter( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processes( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

NG2 plays a role in neuroinflammation but is not expressed by immune cells by Maja Kitic( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

 
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