Strauß, Judith

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier by Judith Hauptmann( )

2 editions published in 2020 in English and held by 5 WorldCat member libraries worldwide

Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. IL-1 signaling in BBB-ECs upregulated the expression of the adhesion molecules Vcam-1, Icam-1 and the chemokine receptor Darc, all of which have been previously shown to promote CNS-specific inflammation. In contrast, IL-1R1 signaling suppressed the expression of the stress-responsive heme catabolizing enzyme heme oxygenase-1 (HO-1) in BBB-ECs, promoting disease progression via a mechanism associated with deregulated expression of the IL-1-responsive genes Vcam1, Icam1 and Ackr1 (Darc). Mechanistically, our data emphasize a functional crosstalk of BBB-EC IL-1 signaling and HO-1, controlling the transcription of downstream proinflammatory genes promoting the pathogenesis of autoimmune neuroinflammation

Zwischen Traum und Wirklichkeit. Reformpädagogik als eine Form von Flucht? Astrid Lindgrens "Pippi Langstrumpf" im Bezug auf die reformpädagogischen Ansätze von Ellen Key und Alexander S. Neill by Judith Strauss( )

2 editions published in 2019 in German and held by 4 WorldCat member libraries worldwide

Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies by Judith Strauß( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity by Martina Ott( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Professionelle und ehrenamtliche ambulante Hospizarbeit im ländlichen Raum by Judith Strauß( Book )

1 edition published in 2018 in German and held by 1 WorldCat member library worldwide

Scriptural Reasoning Theoretische Grundlagen und Praxiserfahrungen( Book )

1 edition published in 2022 in German and held by 0 WorldCat member libraries worldwide