WorldCat Identities

Teisseyre, Paweł

Works: 4 works in 5 publications in 1 language and 9 library holdings
Roles: Other, Author
Publication Timeline
Most widely held works by Paweł Teisseyre
Unveiling new interdependencies between significant DNA methylation sites, gene expression profiles and glioma patients survival by Michal J Dabrowski( )

2 editions published in 2018 in English and held by 3 WorldCat member libraries worldwide

In order to find clinically useful prognostic markers for glioma patients' survival, we employed Monte Carlo Feature Selection and Interdependencies Discovery (MCFS-ID) algorithm on DNA methylation (HumanMethylation450 platform) and RNA-seq datasets from The Cancer Genome Atlas (TCGA) for 88 patients observed until death. The input features were ranked according to their importance in predicting patients' longer (400+ days) or shorter (& lt;= 400 days) survival without prior classification of the patients. Interestingly, out of the 65 most important features found, 63 are methylation sites, and only two mRNAs. Moreover, 61 out of the 63 methylation sites are among those detected by the 450 k array technology, while being absent in the HumanMethylation27. The most important methylation feature (cg15072976) overlaps with the RE1 Silencing Transcription Factor (REST) binding site, and was confirmed to intersect with the REST binding motif in human U87 glioma cells. Six additional methylation sites from the top 63 overlap with REST sites. We found that the methylation status of the cg15072976 site affects transcription factor binding in U87 cells in gel shift assay. The cg15072976 methylation status discriminates & lt;= 400 and 400+ patients in an independent dataset from TCGA and shows positive association with survival time as evidenced by Kaplan-Meier plots
Diversity of editors and teams versus quality of cooperative work: experiments on wikipedia by Marcin Sydow( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Computational methods in data analysis : Information technologies: research and their interdisciplinary applications, Warsaw, 22-24 October 2015 - ITRIA 2015 by ITRIA 2015( Book )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Random Subspace Method for high-dimensional regression with the R package regRSM by Paweł Teisseyre( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Audience Level
Audience Level
  General Special  
Audience level: 0.00 (from 0.00 for Unveiling ... to 0.00 for Unveiling ...)