WorldCat Identities

Le Dréan, Gwenola

Works: 2 works in 2 publications in 1 language and 3 library holdings
Roles: Author, Opponent
Publication Timeline
Most widely held works by Gwenola Le Dréan
Exogenous CCK and gastrin stimulate pancreatic exocrine secretion via CCK-A but also via CCK-B/gastrin receptors in the calf by Gwenola Le Dréan( )

1 edition published in 1999 in English and held by 2 WorldCat member libraries worldwide

The role of dietary sugars in intestinal homeostasis and microbiota composition by Xufei Zhang( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

50% of the adult population cannot fully absorb a load of 25g of fructose, while the average daily intake is ~50g. Thus, changes in the food intake patterns created a condition of fructose malabsorption leading likely to fructose overspill into the distal part of the intestine. Recent insight emphasized the central role of the intestinal homeostasis on the host physiology of and the importance of the interactions between nutrients and microbiota in this process. The overall objective of my PhD was to decipher the role of luminal fructose-induced changes in GI homeostasis in two conditions: fructose malabsorption or fructose normal absorption. Two mouse models were used: a mouse model of fructose malabsorption (ketohexokinase-knockout, KHK-/-) fed 20% fructose and mice model of normal fructose absorption exposed to 15% fructose from drinking solution. In KHK-/-, fructose intake was associated with visceral hyper-sensitivity and changes in microbiota composition and metabolism. These changes in the intestinal ecosystem were able to regulate the pattern of peptide secreted by the enteroendocrine cells of the ileum and caecum by stimulating the secretion of CCK in L cells normally dedicated to the secretion of PYY and GLP1. However, in KHK-/- and WT fructose did not alter the intestinal permeability, even in intestinal regions that developed inflammation in response to fructose intake. This study highlighted the critical role of luminal fructose on intestinal endocrine functions, but not barrier functions within malabsorption and normal absorption conditions, respectively. Potential links between increase in CCK secretion and host physiology need to be further explored
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.98 (from 0.97 for Exogenous ... to 1.00 for Exogenous ...)