WorldCat Identities

Blanche, Stéphane

Works: 50 works in 57 publications in 2 languages and 161 library holdings
Roles: Contributor, Thesis advisor, Opponent, Other, Author, Redactor, Publishing director
Publication Timeline
Most widely held works by Stéphane Blanche
Sida( Book )

4 editions published in 1991 in French and held by 42 WorldCat member libraries worldwide

L'infection à VIH de la mère et de l'enfant( Book )

3 editions published between 1992 and 1998 in French and held by 36 WorldCat member libraries worldwide

Avant tout destiné au praticien, ce guide pratique et consensuel est le fruit de la mise en commun de l'expérience de huit équipes françaises. Il traite tous les aspects médicaux, mais n'oublie pas les problèmes délicats posé par l'accompagnement psychologique et social
Outcome of chronic granulomatous disease - conventional treatment vs stem cell transplantation by Cinzia Dedieu( )

1 edition published in 2021 in English and held by 3 WorldCat member libraries worldwide

Abstract: Background<br>Hematopoietic stem cell transplantation (HSCT) can cure chronic granulomatous disease (CGD), but it remains debated whether all conventionally treated CGD patients benefit from HSCT.<br><br>Methods<br>We retrospectively analyzed 104 conventionally treated CGD patients, of whom 50 patients underwent HSCT.<br><br>Results<br>On conventional treatment, seven patients (13%) died after a median time of 16.2 years (interquartile range [IQR] 7.0-18.0). Survival without severe complications was 10 ± 3% (mean ± SD) at the age of 20 years; 85% of patients developed at least one infection, 76% one non-infectious inflammation. After HSCT, 44 patients (88%) were alive at a median follow-up of 2.3 years (IQR 0.8-4.9): Six patients (12%) died from infections. Survival after HSCT was significantly better for patients transplanted ≤8 years (96 ± 4%) or for patients without active complications at HSCT (100%). Eight patients suffered from graft failure (16%); six (12%) developed acute graft-vs-host disease requiring systemic treatment. Conventionally treated patients developed events that required medical attention at a median frequency of 1.7 (IQR 0.8-3.2) events per year vs 0 (IQR 0.0-0.5) in patients beyond the first year post-HSCT. While most conventionally treated CGD patients failed to thrive, catch-up growth after HSCT in surviving patients reached the individual percentiles at the age of diagnosis of CGD.<br><br>Conclusion<br>Chronic granulomatous disease patients undergoing HSCT until 8 years of age show excellent survival, but young children need more intense conditioning to avoid graft rejection. Risks and benefits of HSCT for adolescents and adults must still be weighed carefully
Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia by Nicolas Degand( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Early diagnosis of HIV-1 infection in newborns, in the context of prevention of mother-to-child transmission with HAART (Perinatal Cohort ANRS Co 01) by Véronique Avettand-Fénoël( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Low prevalence of lipodystrophy in HIV-infected Senegalese children on long-term antiretroviral treatment: the ANRS 12279 MAGGSEN Pediatric Cohort Study by For the MAGGSEN Cohort Study Group( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide


1 edition published in 1996 in French and held by 2 WorldCat member libraries worldwide

A Physiologically-Based Pharmacokinetic Model to Predict Human Fetal Exposure for a Drug Metabolized by Several CYP450 Pathways by Maïlys De Sousa Mendes( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis by Luyan Liu( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Clinical, Functional and Genetic Analysis of Twenty-Four Patients with Chronic Granulomatous Disease - Identification of Eight Novel Mutations in CYBB and NCF2 Genes by Cécile Martel( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Perinatal transmission of Cytomegalovirus (CMV) in children born to HIV positive and negative women in Cameroon by Anfumbom Kfutwah( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome by ANRS French Perinatal Cohort( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

High prevalence of cytomegalovirus (CMV) infection in infants born to HIV infected mothers-ANRS French Perinatal Cohort (EPF) by ANRS French Perinatal Cohort (EPF)( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Description clinique et génétique d'une cohorte européenne de 136 patients atteints de cryopyrinopathies (CAPS) et étude d'une corrélation entre génotype et phénotype by Romain Lévy( Book )

1 edition published in 2014 in French and held by 2 WorldCat member libraries worldwide

Les cryopyrinopathies (ou CAPS pour cryopyrine-associated periodic syndrome) regroupent trois syndromes auto-inflammatoires de gravité croissante dont l'étiologie génétique commune repose sur des mutations gain de fonction du gène NLRP3, et responsables d'une augmentation de la production d'interleukine 1. L'hypothèse d'une corrélation entre génotype et phénotype reste débattue. Dans cette étude, je décris les caractéristiques cliniques de 136 patients atteints de CAPS, issus d'une cohorte internationale européenne, et pour lesquels un séquençage du gène NLRP3 a été réalisé. Une analyse statistique est ensuite détaillée, permettant d'apporter des arguments en faveur d'un certain nombre d'associations entre génotype et phénotype, et de dégager des marqueurs non pas génétiques uniquement mais également cliniques, prédictifs d'une évolution sévère, utiles aux cliniciens en pratique courante
A 1-Year Prospective French Nationwide Study of Emergency Hospital Admissions in Children and Adults with Primary Immunodeficiency by the CEREDIH French PID study group( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Pharmacocinétique de population des antirétroviraux chez la femme enceinte by Nedjma Sihem Benaboud( )

1 edition published in 2012 in French and held by 2 WorldCat member libraries worldwide

Important physiological changes occur during pregnancy. These changes may affect the pharmacokinetics and/or pharmacodynamics of the administered medication. In HIV infected women, antiretroviral treatment adequacy and effectiveness is essential for the health of the mother and for the prevention of HIV transmission to the newborn. For optimal treatment interms of efficacy and tolerance, the effect of pregnancy on antiretroviral concentrations in themother and their transplacental passage have to be assessed.In this work we used the appropriate methodology in this population: non linear mixed effects modeling. Data from therapeutic drug monitoring, as well as data from a multicenter clinical trial (TEmAA) were analyzed using: NONMEM or Monolix. In the first study presented, we investigated the pharmacokinetics of tenofovir in pregnant women. We observed a relatively large effect of pregnancy, a 39% increase of the apparent clearance in pregnant and parturient woman. A dose increase should be therefore investigated in these women. In the second study, we demonstrated a slight increase in lamivudine exposure during pregnancy. This increase does not require dose adjustment. In the third study, the concentration of nevirapinein the mother and her newborn were analyzed and the administration scheme was evaluated.In the last study, based on concentrations of tenofovir and emtricitabine in breast milk that arereported here for the first time in humans, we simulated the concentration profiles obtained ininfants
L'épidémiologie de l'infection VIH chez l'adulte en Guadeloupe : étude à partir de la base de données hospitalière sur l'infection VIH (1988-2009) by Narcisse Elenga( Book )

2 editions published in 2014 in French and held by 2 WorldCat member libraries worldwide

With an accumulated incidence rate of 56 cases per 100 000 inhabitants, Guadeloupe is the second French region most affected by HIV. Most of the publications on HIV/AIDS were essentially descriptive, stemming from annual reports. The Guadeloupean Hospital Database on HIV was scarcely exploited for research. The objective of this work was to estimate the fundamental aspects of HIV/AIDS in Guadeloupe. So late presentation for care, delay between HIV diagnosis and first specialised consultation, follow-up interruption, incidence of depression, opportunistic infections and deaths were studied as well as their predictive factors. We were able to highlight the following points: first, the very late HIV diagnosis (CD4< 200 / mm3) concerned 40, 12 % of HIV- infected adults followed in Guadeloupe. 36 % of patients had delays between HIV diagnosis and first specialised consultation. However, more than 22 % of patients were permanently lost to follow-up and never seen again. The first three classifying affections were oesophageal candidiasis, HIV-wasting syndrome and pneumocystosis. The causes of deaths reported in the literature were similar to those observed in our study. AIDS-related infections were the first cause of deaths.This thesis work thus tried to generate, in one of the most HIV-affected French regions, some indicators from the French Hospital Database on HIV. This database often did not contain all the desired informations, but the important number of observations allowed to have high power for the studied variables. These results, although often confirming the clinicians' empirical knowledge, may help understand some aspects of the HIV epidemic in Guadeloupe
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English (14)

French (12)