WorldCat Identities

Carn, Florent (auteur d'une thèse de Physique)

Overview
Works: 3 works in 3 publications in 1 language and 3 library holdings
Roles: Opponent, Author, Thesis advisor
Publication Timeline
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Most widely held works by Florent Carn
Nanoparticules en environnement cellulaire : Impact de la nano-architecture sur l'internalisation, la biodégradation et les fonctionnalités thérapeutiques. by Anouchka Plan( )

1 edition published in 2019 in French and held by 1 WorldCat member library worldwide

Inorganic nanoparticles represent innovative solution to face current limitations in early diagnostic or targeted therapies.First part focuses on the interactions between magnetic nanoparticles and stem cells to understand better the parameters which impact internalization and biodegradation. We evidenced an impact from the nanoparticle's coating, the presence of proteins and the aggregation. Nanoparticles' impact on cellular differentiation shown a process of re-magnetization of the iron products of degradation for some differentiation ways.In the second part, we studied anti-cancerous hyperthermal therapies and more precisely the impact of the intracellular confinement. We shown that the cellular environment can completely inhibit the heating delivered by magnetic hyperthermia but at the contrary can also be beneficial for applying photothermia at biocompatible wavelengths. Finally, the combination of photothermia with a drug leaded to an increase of the efficiency of both therapies separated with reduces secondary effects
Intégration entre chimie douce et fluides complexes pour la genèse d'architectures poreuses hiérarchisées : synthèses, caractérisations et application by Florent Carn( )

1 edition published in 2006 in French and held by 1 WorldCat member library worldwide

This work deals with the synthesis, characterizations and applications of inorganic monoliths displaying a hierarchical porosity (macro-, meso- and/or microporosity). First, we developed two new synthetic approaches respectively based on sol-gel reactions confined within the continuous phase of either direct emulsions or foams. We established new relations between the final macroporous texture and some physicochemical parameters, which allow tuning the macroporous architecture. The properties and functions related to the scaffold's microstructure have been varied by using either different molecular precursors (silicium, titanium alkoxide) or nanobuilding blocks (SiO2 particles, V2O5 ribbons). Then, we studied the mechanism that governs the inorganic scaffold genesis inside the foam by considering the macroscopic and local drainage of diluted colloidal nanoparticles dispersions. We showed that nanoparticles aggregation preferentially occurs within the node region enhancing thus the interfacial rigidity. We revealed a nanoparticles stabilizing effect at low concentration and we proposed two mineralization mechanisms, toward respectively polymeric and particulate approaches, that allow a better understanding of the material's behaviour in drying condition. Finally, we have synthesized V2O5-carbon nanotubes foams to engineer positive electrode for lithium batteries. Preliminary results indicated that promising performance can be expected if the carbon nanotubes are homogeneously dispersed
Biotransformations, dégradation et cycle de vie des nanoparticules d'or en milieu intracellulaire by Alice Balfourier( )

1 edition published in 2019 in French and held by 1 WorldCat member library worldwide

Gold nanoparticles display unique optical properties, and are considered as promising devices for medical imaging, therapy and diagnostic. Nevertheless, nanoparticles life cycle is still poorly understood at the cellular range. On the short term, nanoparticles are internalized by cells and sequestrated into the lysosomes, which are the intracellular vesicles responsible for the degradation and recycling of damaged endogenous and exogenous compounds. We focus our study on this step of nanoparticle life cycle, and more precisely on the lysosome and its nanoparticles content. Firstly, we studied this system from the lysosome point of view, and the impact of gold nanoparticles on its structural and functional integrity. Secondly, we considered the nanoparticles point of view, and the biotransformation they undergo in the lysosome. Once sequestrated into the lysosome, nanoparticles aggregate which modulate their optical properties, and thus modify their therapeutic potential. In order to capture this first biotransformation, we characterized the nature of these intracellular aggregates, and highlight the therapeutic potential of gold nanosphere aggregates, while they are considered as medically irrelevant when dispersed. Finally, we focus our study on the fate of gold nanoparticles in cells during six months. We demonstrate that gold nanoparticles were degraded in vitro, despite the current dogma that assert that gold nanoparticles are bio-inert. This process was proven to take place within days, and to be followed by the recrystallization of released gold. Transcriptomics analysis of the biological pathways activated in this biodegradation reveals the biological actors involved in this transformation, and to identify similarities between the response to gold nanoparticles and ionic gold, suggesting a common gold metabolism. This analogy opens up new prospects for the understanding of gold nanoparticle life cycle, but also for therapy. To conclude, the work presented in this thesis put into light new steps in gold nanoparticles life cycle, that enable us to propose therapeutic strategy that take advantages from fortuitous phenomena, while keeping in mind nanotoxicological issues
 
Audience Level
0
Audience Level
1
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Audience level: 0.97 (from 0.93 for Intégrati ... to 0.99 for Nanopartic ...)

Alternative Names
Florent Carn wetenschapper

Languages
French (3)