WorldCat Identities

Plavec, Janez

Overview
Works: 623 works in 647 publications in 2 languages and 961 library holdings
Genres: Academic theses 
Roles: Author, Thesis advisor, Other, Editor, Interviewee, dgs, Contributor, Opponent
Publication Timeline
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Most widely held works by Janez Plavec
Nucleic acid-metal ion interactions( )

1 edition published in 2008 in English and held by 78 WorldCat member libraries worldwide

Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists, Natural biochemical processes are routinely being discovered in living cells that involve RNA. Some of these processes, such as RNA interference, are now being exploited for biotechnology and medicinal applications. DNA has also proven in recent years to be more than a passive storehouse of information. For example, non-B-form DNA structures formed by G-rich DNA have been shown to participate in the regulation of gene expression, a discovery that presents new possibilities for drug targets in the genome. The current quest to understand how nucleic acid functions at the most fundamental level requires that we have a detailed understanding of nucleic acid-metal ion interactions. Because RNA and DNA are polyanions the structure and biological function of these biopolymers depends strongly on their association with metal ions. While this intimate connection between metal ions and nucleic function has been appreciated for decades, the noncovalent and dynamic nature of these interactions has continually presented challenges to the development of accurate and quantitative descriptions. Over the past few years the development of solution state spectroscopic techniques and the achievement of high resolution X-ray crystal structures have provided tremendous insights into the nature of nucleic acid-metal ion interactions, including direct evidence for their importance in determining nucleic acid structure, from the dictation of folding pathways followed by large RNA molecules to the subtle modulation of DNA groove widths. This new book provides a comprehensive review of the experimental studies that define our current understanding of nucleic acid-metal ion interactions with a particular emphasis being placed on experimental biophysical studies. However, the book is not merely a current review of the literature, as original material and fresh perspectives on published results are also presented. Particularly noteworthy topics include: -The chapter by Williams and fellow workers which reviews information provided by x-ray crystal structures and discusses what this information has revealed about the unique nature of Mg2+ interactions with RNA phosphate groups. The authors provide fresh insights, based upon structural comparisons, for how these interactions govern the local folding pathways of RNA. By dedicating separate chapters to the participation of metal ions in the kinetics and thermodynamics of RNA folding, this volume provides a more in depth treatise of both areas than is typically possible for reviews in which these two related, but distinct, topics are combined -Polyelectrolyte models of nucleic acids have proven to be extremely valuable for understanding the sequestering counterions in a so-called diffuse cloud around polymeric DNA. J. Michael Schurr provides a comprehensive review of polyanion models. of nucleic acid-metal ion interactions. Despite the success of polyelectrolyte models in describing some physical properties of nucleic acids, this topic is not always sufficiently understood by many researchers to make use of these models and this chapter serves as a valuable and up to date introduction to this topic. -The chapter by Pizarro and Sadler on metal ion-nucleic acid interactions in disease and medicine is complemented by a chapter by Lippert on coordinative bond formation between metal ions and nucleic acid bases. Together, these two chapters provide an overview of transition metal ion interactions with nucleic acids that illustrates the promise and peril that is associated with direct metal ion coordination to nucleic acid bases in living cells. The book is sufficiently detailed to serve as a reference source for researchers active in the field of nucleic acids biophysics and molecular biology. In addition, chapter authors have added introductory material and enough background material in each chapter so that the book can also can serve as an entry point for students and researchers that have not previously worked in the field which will make the book of lasting value and more accessible by a wider audience
Nucleic acid-metal ion interactions by Nicholas V Hud( )

2 editions published in 2008 in Undetermined and English and held by 51 WorldCat member libraries worldwide

Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists
Studies on stereoelectronic effects in nucleosides and nucleotides by Janez Plavec( Book )

5 editions published in 1995 in English and held by 16 WorldCat member libraries worldwide

NMR investigations of G-quadruplex structures by Irene Bessi( )

1 edition published in 2016 in English and held by 16 WorldCat member libraries worldwide

This thesis deals with the NMR characterization of the structure and the folding dynamics of DNA G quadruplexes as potential therapeutic target in cancer therapy and building block for DNA based nanotechnology. The first part of this thesis (Chapters 1-5) introduces the reader to the world of G quadruplexes. The main features of the classic Watson Crick double helix and alternative non B DNA structures are illustrated in Chapter 1. Many different base pairing schemes are possible, besides the canonical Watson Crick motif, thereby expanding the structural complexity of DNA. Non canonical base pairing, such as Hoogsteen hydrogen bonding, enables the assembly of triplets and quartets, which are the building blocks of triplex and quadruplex structures, respectively.
Trends in biomolecular structure : from chemistry to function : programme and book of abstracts, Ljubljana, Slovenia, October 3-5, 2013( Book )

1 edition published in 2013 in English and held by 6 WorldCat member libraries worldwide

Studies on stereoelectronic effects in nucleosides and nucleotides by Janez Plavec( Book )

3 editions published in 1995 in English and held by 5 WorldCat member libraries worldwide

Program and book of abstracts by Structure and Interactions Symposium on Nucleic Acid Chemistry( Book )

1 edition published in 2010 in English and held by 4 WorldCat member libraries worldwide

Strukturne študije človeškega S100A1 proteina : [doktorska disertacija] by Martina Lenarčič Živković( Book )

1 edition published in 2014 in Slovenian and held by 4 WorldCat member libraries worldwide

Breakthroughs in NMR of structural biology by Bio-NMR Annual User Meeting( Book )

1 edition published in 2012 in English and held by 4 WorldCat member libraries worldwide

Interakcije listeriolizina O s holesterolom = Interactions of listeriolysin O with cholesterol : [doktorska disertacija] by Mirijam Kozorog( Book )

1 edition published in 2019 in Slovenian and held by 4 WorldCat member libraries worldwide

Vpliv kemijskih modifikacij in kationov na prostorske strukture oligonukleotidov : doktorsko delo by Peter Podbevšek( Book )

1 edition published in 2011 in Slovenian and held by 4 WorldCat member libraries worldwide

Strukturne raziskave RNA oligonukleotidov udeleženih v kontroli izražanja genov : doktorska disertacija by Mirko Cevec( Book )

1 edition published in 2008 in Slovenian and held by 4 WorldCat member libraries worldwide

Advances in noncanonical nucleic acids : ANNA 2019, Rogaška Slatina, Slovenia, October 17th - 19th, 2019 : [programme and book of abstracts] by Advances in noncanonical nucleic acids (konferenca) :( Book )

1 edition published in 2019 in English and held by 4 WorldCat member libraries worldwide

Sugar-modified guanosine analogs as versatile tools for shaping G-quadruplex architectures by Linn Karen Haase( )

3 editions published between 2020 and 2021 in English and held by 4 WorldCat member libraries worldwide

Magnetische Kernresonanz, Nucleinsäuren, Struktur, guanosine analogs, hydrogen bond, quadruplex, sugar pucker
Strukturne raziskave predorganizacije prostorskih struktur oligomernih nukleinskih kislin : doktorska disertacija by Miha Plevnik( Book )

1 edition published in 2005 in Slovenian and held by 4 WorldCat member libraries worldwide

Študij strukture in konformacijskih ravnotežij gradnikov nukleinskih kislin z NMR spektroskopijo : doktorska disertacija by Matjaž Polak( )

1 edition published in 2000 in Slovenian and held by 4 WorldCat member libraries worldwide

EUROMAR : European Conference on Magnetic Resonance, 5th - 8th July, 2021, Ljubljana : book of abstracts by EUROMAR( Book )

1 edition published in 2021 in English and held by 4 WorldCat member libraries worldwide

 
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Nucleic acid-metal ion interactions Nucleic acid-metal ion interactions
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Nucleic acid-metal ion interactions
Alternative Names
Janez Plavec researcher

Janez Plavec wetenschapper

P., Janez

Plavec, J.

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