WorldCat Identities

Tracqui, Philippe

Overview
Works: 26 works in 43 publications in 2 languages and 1,282 library holdings
Genres: Academic theses 
Roles: Publishing director, Author, Thesis advisor, Opponent, Director
Classifications: QH506, 570
Publication Timeline
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Most widely held works by Philippe Tracqui
Éléments de biologie à l'usage d'autres disciplines : de la structure aux fonctions by J Demongeot( )

12 editions published in 2003 in 3 languages and held by 1,229 WorldCat member libraries worldwide

This collective work offers a compilation of the fundamental notions on animal biology, of molecular and intracellular structures and the presentation of different biological functions
Proceedings of the Autrans seminar on modelling and simulation of biological processes in the context of genomics by Autrans seminar on modelling and simulation of biological processes in th context of genomics( Book )

1 edition published in 2002 in English and held by 6 WorldCat member libraries worldwide

Des concepts de la dynamique non linéaire à l'auto-organisation des systèmes biologiques : attracteurs multiples, structures de bifurcation et trajectoires spatio-temporelles d'un modelé autocatalytique du métabolisme minéral osseux by Philippe Tracqui( Book )

2 editions published in 1990 in French and held by 4 WorldCat member libraries worldwide

DANS LE CADRE DE LA MODELISATION NON LINEAIRE DES SYSTEMES BIOLOGIQUES, CE TRAVAIL EST UNE APPROCHE THEORIQUE DU METABOLISME CALCIQUE IN VIVO QUI PREND EN COMPTE DIFFERENTS NIVEAUX DE SON ORGANISATION DYNAMIQUE. A PARTIR D'UN ECHANTILLONNAGE DE LA CINETIQUE OSCILLANTE D'UN RADIOTRACEUR, NOTRE EQUIPE A ELABORE UN MODELE COMPARTIMENTAL NON LINEAIRE DE CE METABOLISME CHEZ LE RAT QUI INTEGRE SIMULTANEMENT LA QUASI-CONSTANCE DES CONCENTRATIONS DE CALCIUM PLASMATIQUE (HOMEOSTASIE), LA CROISSANCE AVEC L'AGE DE LA MASSE CALCIQUE ET LA DYNAMIQUE CIRCADIENNE AUTO-OSCILLANTE DU METABOLISME MINERAL OSSEUX. CETTE DYNAMIQUE TEMPORELLE AUTO-ENTRETENUE EST GENEREE PAR UNE SOUS UNITE AUTOCATALYTIQUE REPRESENTANT L'INTERFACE OS/LIQUIDES EXTRACELLULAIRES. NOUS PRESENTONS LES PROPRIETES DYNAMIQUES DE CETTE SOUS-UNITE QUI, SUR LE PLAN THEORIQUE ET PHYSIOLOGIQUE, ET AU CUR DU MODELE PROPOSE. CELLE-CI EST D'ABORD APPROXIMEE PAR UN MODELE A DEUX VARIABLES, APPELE SU2. NOUS AVONS MIS EN EVIDENCE UNE COMPLEXITE INATTENDUE DES COMPORTEMENTS DYNAMIQUES DU MODELE SU2 ET EN PARTICULIER L'EXISTENCE DE TOPOLOGIES OU COEXISTENT DEUX TRAJECTOIRES PERIODIQUES STABLES (BIRYTHMICITE). A PARTIR DES DEVELOPPEMENTS DE LA THEORIE DES SINGULARITES, NOUS AVONS CARACTERISE THEORIQUEMENT ET QUANTITATIVEMENT LES CENTRES ORGANISATEURS QUI DETERMINENT LES BIFURCATIONS GOUVERNANT LES TRANSITIONS ENTRE CES TOPOLOGIES. AVEC LA SOUS-UNITE AUTOCATALYTIQUE COMPLETE, COMPRENANT TROIS COMPARTIMENTS, LA BIRYTHMICITE EST ASSOCIEE A DES COMPORTEMENTS TEMPORELS COMPLEXES, PERIODIQUES ET CHAOTIQUES, RESULTANT DE L'EXISTENCE D'UNE TANGENCE HOMOCLINE A UN CYCLE LIMITE INSTABLE. CETTE TRAJECTOIRE HOMOCLINE PARTICULIERE EST UN DES ELEMENTS ORGANISATEURS D'UNE STRUCTURE FRACTALE DE BIFURCATION. L'EXISTENCE DE SEQUENCES DE BIFURCATIONS SIMILAIRES, RAPPORTEES A PROPOS D'EXPERIENCES ELECTROCHIMIQUES DE DISSOLUTION, VIENT CONFORTER L'INTERET ET L'INTERPRETATION DE LA SOUS-UNITE. ENFIN NOUS AVONS MIS EN EVIDENCE DIFFERENTES ORGANISATIONS DYNAMIQUES SPATIO-TEMPORELLES QUI APPARAISSENT LORSQUE L'ON INTRODUIT DES PROCESSUS DE DIFFUSION AU SEIN DU MODELE SU2. L'IMPORTANCE QUE POURRAIENT PRESENTER CERTAINES D'ENTRE ELLES POUR LA COMPREHENSION DE L'ORGANISATION SPATIALE DES AGREGATS DE PHOSPHATE DE CALCIUM DANS L'OSTEOIDE EST DISCUTEE
Caractérisation mécanique et modélisation de gels de fibrine soumis à des contraintes cellulaires : une contribution à l'étude des forces de traction cellulaires by Mohamed Benkherourou( )

2 editions published in 1999 in French and held by 3 WorldCat member libraries worldwide

The Spatio-temporal dynamics of cell membrane deformations and cell migration : a characterization from image sequences and theoretical modelling = Dynamique spatio-temporelle des déformations membranaires et de la migration cellulaire : caractérisation à partir de séquences d'images et de modélisation théorique by Angelique Stephanou( )

2 editions published in 2002 in French and held by 3 WorldCat member libraries worldwide

This thesis concerns the study of cell deformations and is interested in two complementary approaches, an experimental one and another theoretical one. The experimental approach is motivated by the demonstration from previous works of the existence of a certain auto-organization of the deformation patterns. This auto-organization consists of the appearance of recurring protrusive patterns in space and time. This has been shown, in particular, for round-shaped cells (leukocytes or keratinocytes) which present a relatively simple organization of theactin cytoskeleton. We have chosen to study murin fibroblasts (L929 line). The fibroblasts exhibit long membrane extensions such as filopods. This time, this type of protrusion is related to a more complex organization of the actin cytoskeleton, where the filaments tend to form bundles. Our aim has been to determine if there exists a similar self-organized componentof these fibroblasts membrane deformations. Experimental characterization has been performed from image sequences where the cells were observed by phase contrast videomicroscopy. The morphodynamical data of the cells have been extracted from the images with two different methods:(i) a classical segmentation of the cell boundaries for the individual study of each protrusive zone of the cell and (ii) an optical flow method for a global characterizationof the movement of the whole cell. The results obtained show that the cells exhibit mainly symmetrical morphologies with 2 to 4 protrusions. The 4-protrusion state (cross morphology), observed for the most isolated cells, is dynamically characterized by a synchronized pulsating movement between the two perpendicular protrusive directions, where the extension in one direction is accompanied by the simultaneous retraction in the other direction (...) In conclusion, we defined how the work realized experimentally allows us to propose the possibility to use the morphodynamical parameters obtained from the characterization as criteria to identify the cell phenotypes. We also discuss how theoretical modelling can orientate the choice of new experimental protocols
Investigating Metalloproteinases MMP-2 and MMP-9 Mechanosensitivity to Feedback Loops Involved in the Regulation of In Vitro Angiogenesis by Endogenous Mechanical Stresses by Minh-Uyen Dao Thi( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

École de printemps de biologie théorique, Saint-Flour, du 16 au 27 mars 1998 by École de printemps de biologie théorique( Book )

1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide

École de printemps de biologie théorique : Saint-Flour, du 16 au 27 mars 1998 by École de printemps de biologie théorique( Book )

1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide

École de printemps de biologie théorique, Saint-Flour, 16-27 mars 1998 by École de printemps de biologie théorique( Book )

1 edition published in 1998 in French and held by 2 WorldCat member libraries worldwide

Régulation mécanique de l'angiogenèse in vitro : analyse par un modèle aux dérivées partielles des interactions cellules-substrat by Patrick Namy( Book )

2 editions published in 2004 in French and held by 2 WorldCat member libraries worldwide

The outgrowth and formation of new vessels from a pre-existing vascular network, globally defined as angiogenesis, play a crucial role in many physiological and pathological processes, including wound healing and solid tumor growth. In our thesis, we analyze how mechanical factors (stiffness, viscosity, cellular traction) could regulate the capillary network formation. In a real interaction between experiments and modeling, we develop a theoretical biomechanical model of the onset of in vitro angiogenesis, in which angiogenesis is considered as a mechanical instability driven process. Our model is based on partial differential nonlinear equations, that have been solved by the finite element method. Thanks to linear and nonlinear stability analyses of homogenous steady state, we manage to determine the bifurcation points associated to Turing instability. We then extensively study the influence of parameters on network formation. Our numerical results are in very good agreement with experimental ones, obtained by our team or taken from literature. In the second part of this work, we study the mechanical regulation of extracellular matrix degradation. We show that degradation could be a key process of in vitro angiogenesis
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1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

Problèmes inverses en biomécanique : de la caractérisation des propriétés élastiques de cellules adhérentes à l'élaboration d'un outil de mesure des déformations locales au sein des cellules contractiles et de tissus by Alain Caril Kamgoue Tchouassi( Book )

2 editions published in 2009 in French and held by 2 WorldCat member libraries worldwide

The research in cell biology have been heavily marked during the last two decades by taking greater account of the mechanical properties of living cells. The remarkable development of a new discipline, the Mechanobiology, and the study of signaling pathways involved, or mechano-transduction, are tangible signs. In this context, this thesis is a contribution to the characterization of active and passive mechanical properties of adherent cells from their response to stress imposed. This approach, which is defined as a formal resolution of an inverse problem was developed in the first part of our work to identify the intrinsic modulus of adherent cells probed mechanically by optical tweezers or magnetic tweezers. These micromanipulation techniques allow in fact to distort the cytoskeleton of the cell through functionalized beads hanging from the transmembrane receptor in the cell. However, direct analysis of the solicitation/answer couple allows us to infer only the apparent modulus of the cell. The originality of our work is to offer a significant improvement of the cell Young modulus estimation through the consideration of several factors that are geometric: (i) embedding angle of the bead in cell, (ii) the height of the cell under the bead (iii) the curvature of the interface bead/cell. We propose including explicit functions of these parameters to correct the error of cell rigidity when this rigidity is estimated under the assumption of an infinite or semi-infinite medium. The second part of our work, concerns characterization, more complex, of contractile cells active mechanical properties observed by video-microscopy. In this case, the illumination of the cell is the input function, while the scope of movement observed over time is the cellular response. The inverse problem here is to infer the field of intracellular constraints at the origin of displacement observed. To better understand the dynamics of spontaneous contractile isolated cardiomyocytes, we first developed an optical flow algorithm performance based on the correlation of images, which allowed us to quantify accurately the evolution of intracellular deformation at the sarcomere level. From this spatial-temporal strain field, we were able to reconstruct originally intracellular constraints calcium-dependent governing the frequency and magnitude of the contraction of cardiomyocytes. We finally show interest in the prospect of this approach in the tissue with different results of coronary arteries elastography
Computation of Adherent Cell Elasticity for Critical Cell-Bead Geometry in Magnetic Twisting Experiments by Jacques Ohayon( )

1 edition published in 2005 in English and held by 2 WorldCat member libraries worldwide

Hyperstructures, Genome Analysis and I-Cells by Patrick Amar( )

1 edition published in 2002 in English and held by 2 WorldCat member libraries worldwide

Transmission of Mechanical Stresses within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model by Philippe Tracqui( )

1 edition published in 2004 in English and held by 2 WorldCat member libraries worldwide

Proceedings of the XXXIth Seminar of the French-Speaking Society for Theoretical Biology by Eric Fanchon( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Rôle de l'environnement mécanique dans la dynamique des systèmes d'adhérence cellulaire : étude spatio-temporelle de microdomaines d'actine by Olivier Collin( Book )

2 editions published in 2005 in French and held by 2 WorldCat member libraries worldwide

The mechanical properties of the substrates are emerging as an important regulator of cellular adhesion mecanisms. In this thesis, we have been interested in the regulation by the mechanical environ ment of the formation and dynamics of specific action-rich structures, the podosomes. The podosomes are very dynamic punctual adhesion sites to the extracellular matrix and can self-organise in ring-shaped structures named rosettes, which dynamical global behaviour is related to the dynamics ofindividual podosomes. The use of polyacrylamide gels with varying stiffness let us to show that the podosome lifespan and the mean distance seperating them is dependant on the substrate rigidity, though the structural properties of the rosette are constant. Moreover, the analysis of the rosette behaviour based on an optical flow method reveals that these structures exhibit temporal oscillations, which period is independent on the mechanical environment. Hence, we have proposed a tileoretical model orthe rosette formation based on an autocatalyic polymerisation process of the action to account for the self-organised nature of these structures
Model Driven Quantification of Individual and Collective Cell Migration by Caroline Rosello( )

1 edition published in 2004 in English and held by 2 WorldCat member libraries worldwide

An Integrative Model of the Self-Sustained Oscillating Contractions of Cardiac Myocytes by Audrey Pustoc'h( )

1 edition published in 2005 in English and held by 2 WorldCat member libraries worldwide

 
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Languages
French (26)

English (10)