Hauptmann, Judith

Human Argonaute proteins : Analysis of endonucleolytic activity and endogenous phosphorylation sites by Judith Hauptmann( )

2 editions published between 2014 and 2015 in English and held by 28 WorldCat member libraries worldwide

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier by Judith Hauptmann( )

2 editions published in 2020 in English and held by 5 WorldCat member libraries worldwide

Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. IL-1 signaling in BBB-ECs upregulated the expression of the adhesion molecules Vcam-1, Icam-1 and the chemokine receptor Darc, all of which have been previously shown to promote CNS-specific inflammation. In contrast, IL-1R1 signaling suppressed the expression of the stress-responsive heme catabolizing enzyme heme oxygenase-1 (HO-1) in BBB-ECs, promoting disease progression via a mechanism associated with deregulated expression of the IL-1-responsive genes Vcam1, Icam1 and Ackr1 (Darc). Mechanistically, our data emphasize a functional crosstalk of BBB-EC IL-1 signaling and HO-1, controlling the transcription of downstream proinflammatory genes promoting the pathogenesis of autoimmune neuroinflammation

Argonaute Family Protein Expression in Normal Tissue and Cancer Entities by Daniel Völler( )

1 edition published in 2016 in English and held by 3 WorldCat member libraries worldwide

Expression of IL-17F is associated with non-pathogenic Th17 cells by Florian Wanke( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events by Brian B Sørensen( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide