WorldCat Identities

Klein, Matthias 1976-

Overview
Works: 15 works in 19 publications in 2 languages and 58 library holdings
Roles: Author, Other
Classifications: R729.5.G4, 572.865
Publication Timeline
.
Most widely held works by Matthias Klein
Die Bedeutung von NFAT-Transkriptionsfaktoren für die Expression von Mastzell-Cytokinen by Matthias Klein( )

4 editions published between 2006 and 2007 in German and held by 26 WorldCat member libraries worldwide

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier by Judith Hauptmann( )

2 editions published in 2020 in English and held by 5 WorldCat member libraries worldwide

Abstract: The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. IL-1 signaling in BBB-ECs upregulated the expression of the adhesion molecules Vcam-1, Icam-1 and the chemokine receptor Darc, all of which have been previously shown to promote CNS-specific inflammation. In contrast, IL-1R1 signaling suppressed the expression of the stress-responsive heme catabolizing enzyme heme oxygenase-1 (HO-1) in BBB-ECs, promoting disease progression via a mechanism associated with deregulated expression of the IL-1-responsive genes Vcam1, Icam1 and Ackr1 (Darc). Mechanistically, our data emphasize a functional crosstalk of BBB-EC IL-1 signaling and HO-1, controlling the transcription of downstream proinflammatory genes promoting the pathogenesis of autoimmune neuroinflammation
ERK3/MAPK6 controls IL-8 production and chemotaxis by Katarzyna Bogucka( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: ERK3 is a ubiquitously expressed member of the atypical mitogen activated protein kinases (MAPKs) and the physiological significance of its short half-life remains unclear. By employing gastrointestinal 3D organoids, we detect that ERK3 protein levels steadily decrease during epithelial differentiation. ERK3 is not required for 3D growth of human gastric epithelium. However, ERK3 is stabilized and activated in tumorigenic cells, but deteriorates over time in primary cells in response to lipopolysaccharide (LPS). ERK3 is necessary for production of several cellular factors including interleukin-8 (IL-8), in both, normal and tumorigenic cells. Particularly, ERK3 is critical for AP-1 signaling through its interaction and regulation of c-Jun protein. The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophils and monocytes both in vitro and in vivo. Further, knockdown of ERK3 reduces metastatic potential of invasive breast cancer cells. We unveil an ERK3-mediated regulation of IL-8 and epithelial secretome for chemotaxis
Herpes-simplex-Enzephalitis unverzüglich behandeln by Susanne Dyckhoff-Shen( )

1 edition published in 2020 in German and held by 2 WorldCat member libraries worldwide

Update wichtige ZNS-Infektionen( )

1 edition published in 2020 in German and held by 2 WorldCat member libraries worldwide

T cells control chemokine secretion by keratinocytes by Tabea Rauschenberger( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Idarucizumab administration in emergency situations: the Munich Registry of Reversal of Pradaxa® in clinical routine (MR REPAIR) by Clemens Küpper( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo by Johanna Fritscher( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Memory CD4+ T cells lacking expression of CCR7 promote pro-inflammatory cytokine production in patients with diffuse cutaneous systemic sclerosis by Giovanni Almanzar( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages by Toszka Bohn( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Challenges in HSV encephalitis: normocellular CSF, unremarkable CCT, and atypical MRI findings by Jan Philipp Bewersdorf( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Diagnose und Therapie intrazerebraler Abszesse by Matthias Klein( )

1 edition published in 2019 in German and held by 2 WorldCat member libraries worldwide

Fieber -- Kopfschmerzen -- Nackensteife by Stefanie Völk( )

1 edition published in 2019 in German and held by 2 WorldCat member libraries worldwide

Microglial A20 protects the brain form CD8-T cell mediated immunopathology by Alma Nazlie Mohebiany( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis by Ilias Masouris( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  General Special  
Audience level: 0.00 (from 0.00 for Die Bedeut ... to 0.00 for Die Bedeut ...)

Languages
English (11)

German (8)