WorldCat Identities

Grählert, Xina

Overview
Works: 8 works in 15 publications in 2 languages and 64 library holdings
Roles: Author
Publication Timeline
.
Most widely held works by Xina Grählert
Klinische Studien erfolgreich durchführen : ein Leitfaden und Ratgeber für Praxis und Klinik by Alexander Schulze( Book )

4 editions published between 2011 and 2012 in German and held by 43 WorldCat member libraries worldwide

Nach wissenschaftlichen Kriterien aufgebaute klinische Prüfungen bilden das Rückgrat moderner medizinischer Therapie. Das Buch zeigt, wie solche Studien in den Alltag in Klinik und Praxis integriert und erfolgreich durchgeführt werden können. Erfahrungsberichte runden die Darstellungen ab und verdeutlichen ethische Aspekte. Der Buchaufbau folgt den realen Schritten, die Studien in klinischen Einrichtungen durchlaufen. Ärzten, Studienassistenten sowie Monitoren wird so ein Zugang zu dieser komplexen Materie eröffnet. Biographische Informationen Dr. sc. med. Alexander Schulze, niedergel. Fach
Koordinierungszentrum für Klinische Studien Dresden : Schlussbericht für den Zeitraum 01.06.2002-31.12.2009 by Xina Grählert( )

2 editions published in 2009 in German and held by 9 WorldCat member libraries worldwide

Synthese, spektroskopische Charakterisierung und Untersuchung des elektrochromen Verhaltens der Diphthalocyanine des Dysprosiums, Holmiums, Erbiums, Thuliums und Ytterbiums by Xina Grählert( )

4 editions published between 1997 and 1998 in German and held by 6 WorldCat member libraries worldwide

Study protocol for a randomized controlled pilot-trial on the semiocclusive treatment of fingertip amputation injuries using a novel finger cap( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: Introduction: Fingertip amputation injuries are common in all ages. Conservatively treated fingertips can regenerate skin and soft tissues to form a functionally and cosmetically excellent new fingertip. Little is known about this ability that, in humans, is confined to the fingertips. Even less is known about the role of the bacteria that regularly colonize these wounds without negative impact on regeneration and healing. As an alternative to surgery, self-adhesive film dressings are commonly used to establish a wet chamber around the injury. These dressings leak malodorous wound fluid eventually until the wound is dry. Having that into consideration, we have therefore developed a silicone finger cap that forms a mechanically protected, wet chamber around the injury for optimal regeneration conditions. It contains a puncturable reservoir for excess wound fluid, which can be thus routinely analyzed for diagnostic and research purposes. This study protocol explains the first randomized controlled trial (RCT) on the semiocclusive treatment of fingertip amputations in both children and adults comparing traditional film dressings with the novel silicone finger cap. Being the first RCT using 2 medical devices not yet certified for this indication, it will gather valuable information for the understanding of fingertip regeneration and the design of future definitive studies. Methods and analysis: By employing an innovative pseudo-cross-over-design with a dichotomous primary endpoint based on patients preference, this pilot study will gain statistically significant data with a very limited sample size. Our RCT will investigate acceptance, safety, effectiveness, and efficacy of this novel medical device while gathering information on the clinical course and outcome of conservatively treated fingertip injuries. A total of 22 patients older than 2 years will be randomly assigned to start the conservative treatment with either the traditional film-dressing or the novel finger cap. The treatment will be changed to the other alternative for another 2 weeks before the patient or the guardian is confronted with the decision of which method they would prefer for the rest of the treatment (if required). Ethics and dissemination: Ethical approval (EK 148042015) of the study protocol has been obtained from Institutional Review Board at the TU Dresden. The trial is registered at the European Database on Medical Devices (EUDAMED-No.: CIV-15-03-013246) and at ClinicalTrials.gov (NCT03089060)
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.86 (from 0.83 for Klinische ... to 0.93 for Reversal o ...)

Alternative Names
Simon, Xina 1966-

Languages
German (11)

English (4)