WorldCat Identities

Imhof, Axel

Overview
Works: 19 works in 21 publications in 2 languages and 113 library holdings
Roles: dgs, Author, Contributor, Other
Publication Timeline
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Most widely held works by Axel Imhof
Regulation des Transkriptionsfaktors AP-2 während zellulärer Differenzierung und Proliferation by Axel Imhof( Book )

1 edition published in 1995 in German and held by 18 WorldCat member libraries worldwide

Differentielle Kontrolle von Histon-Methylierung und Demethylierung bei der Etablierung des heterochromatischen Gensilencings in Drosophila melanogaster by Sandro Lein( )

3 editions published in 2011 in German and held by 18 WorldCat member libraries worldwide

Heterochromatisation is a substantial principle of gene regulation. Postranslational modifications of histones are important epigenetic marks. The Drosophila Su(var)3-9 is a dominant suppressor of PEV and codes for an H3K9 specific methyltransferase. Gene silencing in PEV can be explained by spreading of heterochromatin. Spreading of H3K9me2 is controlled by SU(VAR)3-9. The removal of euchromatic histonmodifications forms the basis for the assembly of heterochromatic structures. Histone demethylases represent antagonistic enzymes to the class of histone methyltransferases. SU(VAR)3-3 is the Drosophila homolog of the human H3K4/H3K9-demethylase LSD1. Demethylation of H3K4me1/2 by SU(VAR)3-3 facilitates the subsequent methylation of H3K9 by SU(VAR)3-9 during chromatin differentiation. Chromatin differentiation takes place during early embryonic development and is affected by the ecdysone receptor coactivator TAIMAN
Characterization of histone lysine demethylation by Jianhua Li( )

1 edition published in 2016 in English and held by 16 WorldCat member libraries worldwide

Proteomic analysis of assembled chromatin with SWATH-MS by Moritz Völker-Albert( )

1 edition published in 2017 in English and held by 16 WorldCat member libraries worldwide

The Drosophila speciation factor HMR localizes to genomic insulator sites by Thomas Gerland( )

1 edition published in 2017 in English and held by 16 WorldCat member libraries worldwide

Functional characterization of HMGN5 in chromatin architecture and gene expression by Ingrid Carolina Araya Fuenzalida( )

1 edition published in 2018 in English and held by 14 WorldCat member libraries worldwide

Building ProteomeTools based on a complete synthetic human proteome by Daniel Paul Zolg( )

1 edition published in 2019 in English and held by 3 WorldCat member libraries worldwide

Lipids join the post-genomic era by Reinhard Bauer( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Crashkurs MedAT( Book )

1 edition published in 2015 in German and held by 2 WorldCat member libraries worldwide

DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei by Alwine Gassen( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Bioinformatic analysis of proteomics data by Andreas Schmidt( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Crashkurs MedAT Biologie by Magdalena Postruznik( Book )

1 edition published in 2015 in German and held by 2 WorldCat member libraries worldwide

Histon-Modifikationen : Schlüsselfaktoren bei der Etablierung und Aufrechterhaltung stabiler Genexpressionsmuster by Axel Imhof( Book )

1 edition published in 2003 in German and held by 1 WorldCat member library worldwide

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Posttranslational modifications of histone tails are very important for epigenetic gene regulation. The lysine-specific demethylase LSD1 (KDM1A/AOF2) demethylates in vitro predominantly mono- and dimethylated lysine 4 on histone 3 (H3K4) and is a promising target for drug discovery. We report a heterogeneous antibody-based assay, using dissociation-enhanced lanthanide fluorescent immunoassay (DELFIA) for the detection of LSD1 activity. We used a biotinylated histone 3 peptide (amino acids 1-21) with monomethylated lysine 4 (H3K4me) as the substrate for the detection of LSD1 activity with antibody-mediated quantitation of the demethylated product. We have successfully used the assay to measure the potency of reference inhibitors. The advantage of the heterogeneous format is shown with cumarin-based LSD1 inhibitor candidates that we have identified using virtual screening. They had shown good potency in an established LSD1 screening assay. The new heterogeneous assay identified them as false positives, which was verified using mass spectrometry
Histone methylation by the drosophila epigenetic transcriptional regulator Ash1 by Christian Beisel( )

1 edition published in 2002 in English and held by 0 WorldCat member libraries worldwide

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex by Stephanie Link( )

1 edition published in 2018 in English and held by 0 WorldCat member libraries worldwide

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells by Éric Metzger( )

1 edition published in 2019 in English and held by 0 WorldCat member libraries worldwide

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma by Sabine Bachmaier( )

1 edition published in 2019 in English and held by 0 WorldCat member libraries worldwide

<> by Regina Fluhrer( )

1 edition published in 2006 in English and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.92 (from 0.88 for Characteri ... to 1.00 for Building P ...)

Languages
English (14)

German (7)