WorldCat Identities

Williamson, Adam 1676?-1747

Overview
Works: 22 works in 33 publications in 3 languages and 299 library holdings
Genres: History  Biography 
Roles: Performer
Classifications: AC4, 942.1
Publication Timeline
Key
Publications about  Adam Williamson Publications about Adam Williamson
Publications by  Adam Williamson Publications by Adam Williamson
posthumous Publications by Adam Williamson, published posthumously.
Most widely held works by Adam Williamson
The official diary of Lieutenant-General Adam Williamson, deputy-lieutenant of the Tower of London, 1722-1747 by Adam Williamson ( Book )
7 editions published between 1912 and 2010 in English and held by 246 WorldCat member libraries worldwide
Military memoirs and maxims of Marshal Turenne : interspersed with others taken from the best authors and observation, with remarks by Henri de La Tour d'Auvergne Turenne ( Book )
3 editions published between 1740 and 1744 in English and held by 26 WorldCat member libraries worldwide
[Military Memoirs and Maxims of Marshall Turenne, interspersed with others taken from the best authors, ... with remarks by A. Williamson.] by Henri de LA TOUR D'AUVERGNE ( Book )
4 editions published between 1740 and 1744 in English and Undetermined and held by 4 WorldCat member libraries worldwide
The official diary of Lieutenant-General Adam Williamson by Adam Williamson ( Book )
1 edition published in 1912 in English and held by 4 WorldCat member libraries worldwide
Mechanisms of Ubiquitin-Driven Cell Cycle Control by Adam Williamson ( )
1 edition published in 2012 in English and held by 3 WorldCat member libraries worldwide
Posttranslational modification of proteins with ubiquitin, ubiquitylation, is essential in all eukaryotes. Ubiquitylation is accomplished by an enzymatic cascade: E1 activates ubiquitin and transfers it to E2, which works with E3 to transfer ubiquitin to substrate residues, usually lysines. Once attachment of the first ubiquitins to substrate, chain initiation, has occurred, E2 and E3 modify one of the seven lysine residues in ubiquitin itself, resulting in formation of polymeric ubiquitin chains, chain elongation. Ubiquitylation is involved in nearly every cellular process, and is central to cell cycle control. Ubiquitin-dependent protein degradation is especially important during mitosis, as cells must turn over many proteins within a short time-window. The anaphase-promoting complex (APC/C) is an essential E3 that targets cell cycle regulators for degradation during mitosis. The APC/C must degrade many substrates within a short period of time, and likely acts under saturation. Furthermore, APC/C substrates are required at different times during mitosis. Therefore, the APC/C cannot degrade all substrate at once, but rather must order substrate degradation so that substrate proteins can accomplish their functions. The balance between efficiency and regulated degradation is the APC/C's major challenge as it orchestrates mitotic exit. In this dissertation I address how human APC/C targets its many substrates for degradation. First, I report our finding that APC/C functions by decorating its substrates with Lys11-linked ubiquitin chains. Lys11-linked chains target substrates to the 26S proteasome and are essential for cell division in human cells, Drosophila cells, and Xenopus tropicalis embryos. The human APC/C uses a dedicated E2, Ube2C/UbcH10, to perform chain initiation while a second E2, Ube2S, elongates these first modifications using exclusively Lys11 on ubiquitin. Ube2C and Ube2S likely function simultaneously, thus allowing APC/C to overcome its massive substrate workload. Efficient chain initiation by Ube2C is made possible by conserved initiation motifs in substrates. Initiation motifs do not regulate substrate binding to APC/C, but instead control the efficiency with which Ube2C and APC/C attach the first ubiquitin moieties to substrates. I will show that chain initiation by Ube2C is the rate-limiting, regulated step during Lys11-linked chain formation by the APC/C. Once Ube2C has initiated chains on APC/C substrates, Ube2S takes over, rapidly elongating Lys11-linked ubiquitin chains that target substrates to the 26S proteasome. Finally, I address how use of two E2 enzymes performing different functions allows APC/C to overcome its major challenge: rapid yet regulated turnover of essential cell cycle regulators. The separation of ubiquitin chain formation by the APC/C into initiation and elongation steps, with initiation being rate-limiting and tightly regulated, draws parallels between ubiquitylation and other processive reactions such as transcription and translation
Military memoirs and maxims of Marshal Turenne. Interspersed with others, taken from the best authors and observation, with remarks. By A. Williamson, Major-General. Aut nunquam tentes, aut perfice by Henri de La Tour d'Auvergne Turenne ( Book )
1 edition published in 1744 in English and held by 2 WorldCat member libraries worldwide
Military memories and maxims of marshal Turenne interspersed with others ( Book )
1 edition published in 1740 in English and held by 1 WorldCat member library worldwide
Official diary of lieutenant general adam williamson, deputy lieutenant of the tower of london by Adam Williamson ( Book )
in English and held by 1 WorldCat member library worldwide
The official diary of Adam Williamson, deputy lieutenant of the Town of London 1722-1747 by Adam Williamson ( Book )
1 edition published in 1912 in English and held by 1 WorldCat member library worldwide
The official diary of Lieutenant-General Adam Williamson, deputy-lieutenant of the Tower of London, 1722-1747 by Adam Williamson ( )
1 edition published in 1912 in Undetermined and held by 1 WorldCat member library worldwide
The official Diary of Lt.-Gen. Adam Williamson, Deputy-Lt. of the Tower of London 1722-1747 by Adam Williamson ( Book )
1 edition published in 1912 in English and held by 1 WorldCat member library worldwide
The United States Coast Guard Saxophone Quartet October 28, 2010 ( Recording )
1 edition published in 2010 and held by 1 WorldCat member library worldwide
Military memoirs and maxims of Marshal Turenne. : Interspersed with others, taken from the best authors and observations and remarks. By A. Williamson by Adam Williamson ( Book )
1 edition published in 1740 in English and held by 1 WorldCat member library worldwide
Military memoirs and maxims of marshal Turenne, interspersed with others and taken from the best authors and observation, with remarks, by A. Williamson by Adam Williamson ( Book )
1 edition published in 1740 in English and held by 1 WorldCat member library worldwide
Lettre à M. Bryan Edwards ... en réfutation de son ouvrage, intitulé, Vues historiques sur la colonie française de Saint-Domingue by P. F Venault de Charmilly ( )
1 edition published in 2005 in French and held by 1 WorldCat member library worldwide
Krygskundige onderrigtingen en grondregelen van den maarschalk de Turenne, en van anderen. by Adam Williamson ( Book )
1 edition published in 1748 in Dutch and held by 1 WorldCat member library worldwide
The impact of formulaic writing on performance and attitudes of writing students by Adam Williamson ( Book )
1 edition published in 2008 in English and held by 1 WorldCat member library worldwide
Military memoirs and maxims of Marshall Turenne. Interspersed with others, taken from the best authors and observation, with remarks by Adam Williamson ( Book )
1 edition published in 1740 in English and held by 1 WorldCat member library worldwide
Official diary The official diary of lieutenant-general Adam Williamson, deputy-lieutenant of the Tower of London : 1722-1747 by Adam Williamson ( Book )
1 edition published in 1912 in English and held by 0 WorldCat member libraries worldwide
Children of the wind : the thousand year journey of the gypsies/ Nigel Williamson (samenst.) ; Adam Williamson (samenst. ) ( Recording )
1 edition published in 2001 in Undetermined and held by 0 WorldCat member libraries worldwide
 
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Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.79 (from 0.00 for [Military ... to 1.00 for Mechanisms ...)
Languages
English (26)
French (2)
Dutch (1)