WorldCat Identities

Voorberg, Jan

Overview
Works: 17 works in 17 publications in 2 languages and 33 library holdings
Roles: Other, Contributor
Publication Timeline
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Most widely held works by Jan Voorberg
Biogenesis and exocytosis of Weibel-Palade bodies by Jan A van Mourik( )

1 edition published in 2002 in English and held by 2 WorldCat member libraries worldwide

Phage Display Technology: A Tool to Explore the Diversity of Inhibitors to Blood Coagulation Factor VIII( )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Fronte del porto : un moderno villaggio urbano a Amsterdam-Nord by Rem Koolhaas( )

1 edition published in 1982 in Italian and held by 2 WorldCat member libraries worldwide

Immunobiology of Inhibitor Development in Hemophilia A( )

1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide

Inhibitors in Nonsevere Hemophilia A: What Is Known and Searching for the Unknown( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg593 to Cys substitution( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Longitudinal Analysis of Factor VIII Inhibitors in a Previously Untreated Mild Haemophilia A Patient with an Arg593→Cys Substitution( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry by Maaike Rijkers( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Small GTP-binding Protein RalA Associates with Weibel-Palade Bodies in Endothelial Cells( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : Dendritic cells (DCs) are the major professional APCs of the immune system; however, their MHC-II-associated peptide repertoires have been hard to analyze, mostly because of their scarce presence in blood and tissues. In vitro matured human monocyte-derived DCs (MoDCs) are widely used as professional APCs in experimental systems. In this work, we have applied mass spectrometry to identify the HLA-DR-associated self-peptide repertoires from small numbers of mature MoDCs (∼5 × 10 6 cells), derived from 7 different donors. Repertoires of 9 different HLA-DR alleles were defined from analysis of 1319 peptides, showing the expected characteristics of MHC-II-associated peptides. Most peptides identified were predicted high binders for their respective allele, formed nested sets, and belonged to endo-lysosomal pathway-degraded proteins. Approximately 20% of the peptides were derived from cytosolic and nuclear proteins, a recurrent finding in HLA-DR peptide repertoires. Of interest, most of these peptides corresponded to single sequences, did not form nested sets, and were located at the C terminus of the parental protein, which suggested alternative processing. Analysis of cleavage patterns for terminal peptides predominantly showed aspartic acid before the cleavage site of both C- and N-terminal peptides and proline immediately after the cleavage site in C-terminal peptides. Proline was also frequent next to the cut sites of internal peptides. These data provide new insights into the Ag processing capabilities of DCs. The relevance of these processing pathways and their contribution to response to infection, tolerance induction, or autoimmunity deserve further analysis. Abstract : Human DCs present standard HLA-DR peptides repertoires, but also C-terminal peptides from cytosolic proteins and Asp as a major cleavage residue, suggesting non-conventional processing pathways
 
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Jan Voorberg

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