WorldCat Identities

Steere, Allen C.

Overview
Works: 31 works in 38 publications in 1 language and 63 library holdings
Genres: Educational films  Internet videos  Educational television programs  Conference papers and proceedings  Handbooks and manuals  Juvenile works  Popular works  Textbooks  History  Criticism, interpretation, etc 
Roles: Creator, Contributor, Author, Editor
Classifications: RC46, 616
Publication Timeline
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Most widely held works about Allen C Steere
 
Most widely held works by Allen C Steere
Lyme disease : first international symposium by Lauri E Markowitz( Book )

4 editions published between 1984 and 1986 in English and held by 25 WorldCat member libraries worldwide

First International Symposium on Lyme Disease by International Symposium on Lyme Disease and Related Disorders( Book )

2 editions published in 1984 in English and held by 4 WorldCat member libraries worldwide

Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis by Sheila L Arvikar( )

2 editions published in 2013 in English and held by 3 WorldCat member libraries worldwide

Introduction: Prior studies have demonstrated an increased frequency of antibodies to Porphyromonas gingivalis (Pg), a leading agent of periodontal disease, in rheumatoid arthritis (RA) patients. However, these patients generally had long-standing disease, and clinical associations with these antibodies were inconsistent. Our goal was to examine Pg antibody responses and their clinical associations in patients with early RA prior to and after diseasemodifying antirheumatic drug (DMARD) therapy. Methods: Serum samples from 50 DMARD-naïve RA patients were tested using an enzyme-linked immunosorbent assay with whole-Pg sonicate. For comparison, serum samples were tested from patients with late RA, patients with other connective tissue diseases (CTDs), age-similar healthy hospital personnel and blood bank donors. Pg antibody responses in early RA patients were correlated with standard RA biomarkers, measures of disease activity and function. Results: At the time of enrollment, 17 (34%) of the 50 patients with early RA had positive immunoglobulin G (IgG) antibody responses to Pg, as did 13 (30%) of the 43 patients with late RA. RA patients had significantly higher Pg antibody responses than healthy hospital personnel and blood bank donors (P < 0.0001). Additionally, RA patients tended to have higher Pg antibody reactivity than patients with other CTDs (P = 0.1), and CTD patients tended to have higher Pg responses than healthy participants (P = 0.07). Compared with Pg antibody-negative patients, early RA patients with positive Pg responses more often had anti-cyclic citrullinated peptide (anti-CCP) antibody reactivity, their anti-CCP levels were significantly higher (P = 0.03) and the levels of anti-Pg antibodies correlated directly with anti-CCP levels (P < 0.01). Furthermore, at the time of study entry, the Pg-positive antibody group had greater rheumatoid factor values (P = 0.04) and higher inflammatory markers (erythrocyte sedimentation rate, or ESR) (P = 0.05), and they tended to have higher disease activity scores (Disease Activity Score based on 28-joint count (DAS28)-ESR and Clinical Disease Activity Index) and more functional impairment (Health Assessment Questionnaire). In Pg-positive patients, greater disease activity was still apparent after 12 months of DMARD therapy. Conclusions: A subset of early RA patients had positive Pg antibody responses. The responses correlated with anti- CCP antibody reactivity and to a lesser degree with ESR values. There was a trend toward greater disease activity in Pg-positive patients, and this trend remained after 12 months of DMARD therapy. These findings are consistent with a role for Pg in disease pathogenesis in a subset of RA patients
Borrelia burgdorferistimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis by Junghee J Shin( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Harrison's principles of internal medicine by Tinsley Randolph Harrison( )

2 editions published in 2011 in English and held by 2 WorldCat member libraries worldwide

From opening presentations of hot topics in medicine such as the growth of evidence-based medicine, the prominence of managed care, and the explosion of information in fundamental areas such as the genetics of disease, to its popular 55-chapter section on the cardinal signs of illness to comprehensive coverage of all major diseases in all organ systems, Harrison's is the internal medicine reference of choice
Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: Prevotella copri, an intestinal microbe, may overexpand in stool samples from patients with new-onset rheumatoid arthritis (RA), but it is not yet clear whether the organism has immune relevance in RA pathogenesis. Methods: HLA-DR-presented peptides (T cell epitopes) from P copri were sought directly in the patients' synovial tissue or peripheral blood mononuclear cell (PBMC) samples using tandem mass spectrometry. The antigenicity of peptides or their source proteins was examined in samples from the RA patients or comparison groups. T cell reactivity was determined by enzyme-linked immunospot assay; antibody responses were measured by enzyme-linked immunosorbent assay, and cytokine/chemokine determinations were made by bead-based assays. Serum and synovial fluid samples were examined for 16S ribosomal DNA for P copri using nested polymerase chain reaction analysis. Results: In PBMCs, we identified an HLA-DR-presented peptide from a 27-kd protein of P copri (Pc -p27), which stimulated Th1 responses in 42% of patients with new-onset RA. In both new-onset RA patients and chronic RA patients, 1 subgroup had IgA antibody responses to either Pc -p27 or the whole organism, which correlated with Th17 cytokine responses and frequent anti-citrullinated protein antibodies (ACPAs). The other subgroup had IgG P copri antibodies, which were associated with Prevotella DNA in synovial fluid, P copri -specific Th1 responses, and less frequent ACPAs. In contrast, P copri antibody responses were rarely found in patients with other rheumatic diseases or in healthy controls. Conclusion: Subgroups of RA patients have differential IgG or IgA immune reactivity with P copri, which appears to be specific for this disease. These observations provide evidence that P copri is immune-relevant in RA pathogenesis
Lyme Disease by Lyme Disease Foundation( Visual )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

With wild deer and deer ticks increasingly common in suburban areas, Lyme disease has become a serious public health threat. This program familiarizes viewers with the symptoms of and treatments for Lyme disease, while providing additional information on how to prevent deer tick bites. Case studies feature a woman hospitalized with the illness after sustaining a tick bite hidden in her hair, and two patients who both contracted Lyme disease from deer ticks yet experienced widely varying symptoms and effects. The program includes the expert commentary of two authorities on Lyme disease: Dr Leila Zackrison, a rheumatologist, and Dr. Gary Manko, an internist
Business and its relationships with government : the progressive revolution by Allen C Steere( )

1 edition published in 1967 in English and held by 1 WorldCat member library worldwide

Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthritis Following Lyme Disease( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: To describe systemic autoimmune joint diseases that develop following Lyme disease, and to compare their clinical features with those of Lyme arthritis (LA). Methods: We reviewed records of all adult patients referred to our LA clinic over a 13-year period, in whom we had diagnosed a systemic autoimmune joint disease following Lyme disease. For comparison, records of patients enrolled in our LA cohort over the most recent 2-year period were analyzed. Levels of IgG antibodies to Borrelia burgdorferi and to 3 Lyme disease-associated autoantigens were measured. Results: We identified 30 patients who had developed a new-onset systemic autoimmune joint disorder a median of 4 months after Lyme disease (usually manifested by erythema migrans [EM]). Fifteen had rheumatoid arthritis (RA), 13 had psoriatic arthritis (PsA), and 2 had peripheral spondyloarthritis (SpA). The 30 patients typically had polyarthritis, and those with PsA or SpA often had previous psoriasis, axial involvement, or enthesitis. In the comparison group of 43 patients with LA, the usual clinical picture was monoarticular knee arthritis, without prior EM. Most of the patients with systemic autoimmune joint disorders were positive for B burgdorferi IgG antibodies, as detected by enzyme-linked immunosorbent assay, but had significantly lower titers and lower frequencies of Lyme disease-associated autoantibodies than patients with LA. Prior to our evaluation, these patients had often received additional antibiotics for presumed LA, without benefit. We prescribed antiinflammatory agents, most commonly disease-modifying antirheumatic drugs, resulting in improvement. Conclusion: Systemic autoimmune joint diseases (i.e., RA, PsA, SpA) may follow Lyme disease. Development of polyarthritis after antibiotic-treated EM, previous psoriasis, or low-titer B burgdorferi antibodies may provide insight into the correct diagnosis
Joseph Rudyard Kipling by Allen C Steere( )

1 edition published in 1977 in English and held by 1 WorldCat member library worldwide

The Panama Canal : old problems and new prospects by Allen C Steere( )

1 edition published in 1989 in English and held by 1 WorldCat member library worldwide

First International Symposium on Lyme Disease Yale Univ. School of Med., Nov. 16-18, 1983 by International Symposium on Lyme Disease( Book )

2 editions published in 1984 in English and held by 1 WorldCat member library worldwide

MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: Lyme arthritis (LA) is caused by infection with Borrelia burgdorferi and usually resolves following spirochetal killing with antibiotics. However, in some patients, arthritis persists after antibiotic therapy. To provide insights into underlying pathogenic processes associated with antibiotic-refractory LA (postinfectious LA), we analyzed differences in microRNA (miRNA) expression between LA patients with active infection and those with postinfectious LA. Methods: MicroRNA expression was assayed in synovial fluid (SF) from LA patients before and after oral and intravenous antibiotic therapy, and in synovial tissue obtained months after antibiotic therapy from patients with postinfectious LA. SF and tissue from patients with other forms of arthritis, such as rheumatoid arthritis (RA) and osteoarthritis, were used for comparison. Results: SF from LA patients during active infection had marked elevations of white blood cells, particularly polymorphonuclear leukocytes, accompanied by elevated levels of microRNA-223 (miR-223). In contrast, SF from postantibiotic LA patients contained greater percentages of lymphocytes and mononuclear cells. SF from postantibiotic LA patients also exhibited marked inflammatory (miR-146a, miR-155), wound repair (miR-142), and proliferative (miR-17-92) miRNA signatures, and higher levels of these miRNAs correlated with longer arthritis duration. Levels of miR-146a, miR-155, miR-142, miR-223, and miR-17-92 were also elevated in synovial tissue in late postinfectious LA, and levels of let-7a were reduced, similar to RA. Conclusion: During active infection, miRNA expression in SF reflected an immune response associated with bacterial killing, while in postinfectious LA, miRNA expression in SF and synovial tissue reflected chronic inflammation, synovial proliferation, and breakdown of wound repair processes, showing that the nature of the arthritis was altered after spirochetal killing
An overview of Quest Club, yesterday and today by Allen C Steere( Book )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

Samuel W. Fletcher, 1903-1987 by Allen C Steere( )

1 edition published in 1987 in English and held by 1 WorldCat member library worldwide

Antibodies to Endothelial Cell Growth Factor and Obliterative Microvascular Lesions in the Synovium of Patients With Antibiotic-Refractory Lyme Arthritis( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Abstract Objective Endothelial cell growth factor (ECGF) was recently identified as the first autoantigen known to be a target of T cell and B cell responses in ∼20% of patients with antibiotic-refractory Lyme arthritis. The goal of the current study was to look for a pathologic correlate between ECGF autoantibody responses and histologic findings in synovial tissue. Methods Synovial tissue was examined from 14 patients with antibiotic-refractory Lyme arthritis and 6 patients with other forms of chronic inflammatory arthritis, primarily rheumatoid arthritis. The tissue sections were subjected to chemical and immunostaining, and IgG antibody responses to ECGF were determined by enzyme-linked immunosorbent assay (ELISA). Each finding was ranked for statistical analysis. Results In each disease, synovial tissue showed synovial hypertrophy, vascular proliferation, immune cell infiltrates, and fibrosis. However, among the 14 patients with antibiotic-refractory arthritis, 8 (57%) had obliterative microvascular lesions in the tissue, compared with none of the 6 patients with other forms of chronic inflammatory arthritis (P = 0.04). Among the patients with Lyme arthritis, 5 (36%) had autoantibody responses to ECGF, and all 5 had obliterative lesions, as compared with only 3 of 9 patients who lacked ECGF antibody responses (P = 0.009). Moreover, the magnitude of ECGF antibody responses correlated directly with the extent of obliterative lesions (P = 0.02) and with greater vascularity in the tissue (P = 0.05). Conclusion The correlations of ECGF autoantibody reactivity with obliterative microvascular lesions imply that these autoantibodies may be involved in the obliterative process, suggesting that anti-ECGF antibodies have specific pathologic consequences in the synovial tissue of patients with antibiotic-refractory Lyme arthritis
New ways of handling criminals by Allen C Steere( )

1 edition published in 1973 in English and held by 1 WorldCat member library worldwide

Differences in genotype, clinical features, and inflammatory potential of Borrelia burgdorferi sensu stricto strains from Europe and the United States( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential. Analysis of outer surface protein C and multilocus sequence typing showed that strains from these 2 regions represent distinct genotypes. Clinical features of infection with B. burgdorferi in Slovenia were similar to infection with B. afzelii or B. garinii the other 2 Borrelia spp. that cause disease in Europe, whereas B. burgdorferi strains from the United States were associated with more severe disease. Moreover, B. burgdorferi strains from the United States induced peripheral blood mononuclear cells to secrete higher levels of cytokines and chemokines associated with innate and Th1-adaptive immune responses, whereas strains from Europe induced greater Th17-associated responses. Thus, strains of the same B. burgdorferi species from Europe and the United States represent distinct clonal lineages that vary in virulence and inflammatory potential
The elucidation of Lyme arthritis( Visual )

1 edition published in 1999 in English and held by 1 WorldCat member library worldwide

NIH update : National Institute of Arthritis and Musculoskeletal and Skin Diseases( Visual )

1 edition published in 1988 in English and held by 1 WorldCat member library worldwide

Presents an overview of the work of this institute created in 1986 to focus on rheumatic diseases. Current research on osteoporosis, the recently identified Lyme disease, sports medicine, lupus, and other disorders is reviewed
 
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Alternative Names
Allen Steere académicu estauxunidense

Allen Steere American rheumatologist

Allen Steere Amerikaans academicus

Allen Steere United States of America karimba ŋun nyɛ doo

Steere, Alan

Steere, Alien C.

Steere, Allen C

ألين ستيري

Languages
English (30)