WorldCat Identities

Durán, Mercedes

Overview
Works: 31 works in 60 publications in 3 languages and 134 library holdings
Genres: History 
Roles: Author, Contributor, Other, Publishing director
Publication Timeline
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Most widely held works by Mercedes Durán
Iconografía de los mosaicos romanos en la Hispania alto-imperial by Mercedes Durán( Book )

13 editions published in 1993 in Spanish and Undetermined and held by 66 WorldCat member libraries worldwide

Estudio iconográfico de los mosaicos romanos en la Hispania alto-imperial by Mercedes Durán( Book )

5 editions published between 1990 and 1992 in Spanish and Undetermined and held by 7 WorldCat member libraries worldwide

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers by Antonis C Antoniou( )

3 editions published between 2012 and 2016 in English and held by 5 WorldCat member libraries worldwide

Introduction: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2). Methods: To evaluate whether these single nucleotide polymorphisms (SNPs) are associated with breast cancer risk for BRCA1 and BRCA2 carriers, we genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers and analysed the associations with breast cancer risk within a retrospective likelihood framework. Results: Only SNP rs10771399 near PTHLH was associated with breast cancer risk for BRCA1 mutation carriers (per-allele hazard ratio (HR) = 0.87, 95% CI: 0.81 to 0.94, P-trend = 3 x 10( -4)). The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 x 10( -5), P-difference = 0.03). Four SNPs were associated with the risk of breast cancer for BRCA2 mutation carriers: rs10995190, P-trend = 0.015; rs1011970, P-trend = 0.048; rs865686, 2df P = 0.007; rs1292011 2df P = 0.03. rs10771399 (PTHLH) was predominantly associated with estrogen receptor (ER)-negative breast cancer for BRCA1 mutation carriers (HR = 0.81, 95% CI: 0.74 to 0.90, P-trend = 4 x 10( -5)) and there was marginal evidence of association with ER- negative breast cancer for BRCA2 mutation carriers (HR = 0.78, 95% CI: 0.62 to 1.00, P-trend = 0.049). Conclusions: The present findings, in combination with previously identified modifiers of risk, will ultimately lead to more accurate risk prediction and an improved understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers
El Poblament de Reixac als segles X i XI by Jaume Alcázar( Book )

2 editions published in 1992 in Catalan and held by 5 WorldCat member libraries worldwide

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers by Karoline B Kuchenbäcker( )

2 editions published between 2014 and 2015 in English and held by 4 WorldCat member libraries worldwide

Imperialisme i colonialisme : 1898: una guerra, un alliberament o una nova dependència? : un ensenyament per pensar by Mercedes Durán( Book )

2 editions published in 1998 in Catalan and held by 4 WorldCat member libraries worldwide

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 by Anna Marie Mulligan( )

2 editions published in 2011 in English and held by 3 WorldCat member libraries worldwide

Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. less thanbrgreater than less thanbrgreater thanMethods: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. less thanbrgreater than less thanbrgreater thanResults: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 x 10( -6)). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. less thanbrgreater than less thanbrgreater thanConclusions: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk by Fergus J Couch( )

2 editions published between 2013 and 2016 in English and held by 3 WorldCat member libraries worldwide

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 x 10( -8), HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4 x 10( -8), HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4 x 10( -8), HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2 x 10( -4)). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%-50% compared to 81%-100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers
Montcada i Reixac i el seu entorn : guia històrico-artística by Mercedes Durán( Book )

2 editions published in 1987 in Catalan and held by 3 WorldCat member libraries worldwide

La Indústria moderna a Catalunya: un exemple, Montcada i Reixac : dossier de l'alumne : crèdit variable de geografia, ensenyament secundari obligatori by Mercedes Durán( Book )

2 editions published in 1994 in Spanish and Catalan and held by 2 WorldCat member libraries worldwide

Comprehensive splicing functional analysis of DNA variants of the BRCA2 gene by hybrid minigenes by Alberto Acedo( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

High proportion of novel mutations of BRCA1 and BRCA2 in breast/ovarian cancer patients from Castilla-León (central Spain) by Mar Infante( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Genetic dissection of the BRCA2 promoter and transcriptional impact of DNA variants by Eugenia Fraile-Bethencourt( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers by Roger L Milne( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers by Ana Osorio( )

2 editions published in 2015 in English and held by 2 WorldCat member libraries worldwide

BRCA1 and BRCA2 mutations in males with familial breast and ovarian cancer syndrome. Results of a Spanish multicenter study by Inmaculada de Juan( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation by Ana Peixoto( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Nuevos mosaicos de la Villa dels Munts en Altafulla, Tarragona : apreciaciones iconográficas by Mercedes Durán( Book )

2 editions published in 2000 in Spanish and held by 2 WorldCat member libraries worldwide

Utilización e interconexión de los esquemas compositivos en los mosaicos figurados de Italia, Galia e Hispania durante el Alto Imperio by Mercedes Durán( Book )

3 editions published in 2000 in Spanish and held by 2 WorldCat member libraries worldwide

Two founder BRCA2 mutations predispose to breast cancer in young women by Mar Infante( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

 
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Audience Level
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  Kids General Special  
Audience level: 0.90 (from 0.85 for Iconografi ... to 0.98 for Imperialis ...)

Alternative Names
Duran, Mercè

Duran, Mercè Durán Penedo

Durán, Mercedes 1950-

Durán Penedo, M.

Durán Penedo, Mercedes 1950-

Penedo, Mercedes Durán 1950-

Languages
Spanish (21)

English (18)

Catalan (7)