WorldCat Identities

Botti, Gerardo

Overview
Works: 68 works in 70 publications in 1 language and 138 library holdings
Roles: Contributor, Other, Author
Publication Timeline
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Most widely held works by Gerardo Botti
AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment by Emilia Caputo( )

2 editions published between 2014 and 2015 in English and held by 4 WorldCat member libraries worldwide

Cancer classification using the Immunoscore: a worldwide task force by Jerome Galon( )

2 editions published in 2012 in English and held by 3 WorldCat member libraries worldwide

Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM classification) summarizes data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N) and evidence for metastases (M). However, it is now recognized that clinical outcome can significantly vary among patients within the same stage. The current classification provides limited prognostic information, and does not predict response to therapy. Recent literature has alluded to the importance of the host immune system in controlling tumor progression. Thus, evidence supports the notion to include immunological biomarkers, implemented as a tool for the prediction of prognosis and response to therapy. Accumulating data, collected from large cohorts of human cancers, has demonstrated the impact of immune-classification, which has a prognostic value that may add to the significance of the AJCC/UICC TNM-classification. It is therefore imperative to begin to incorporate the ` Immunoscore' into traditional classification, thus providing an essential prognostic and potentially predictive tool. Introduction of this parameter as a biomarker to classify cancers, as part of routine diagnostic and prognostic assessment of tumors, will facilitate clinical decision-making including rational stratification of patient treatment. Equally, the inherent complexity of quantitative immunohistochemistry, in conjunction with protocol variation across laboratories, analysis of different immune cell types, inconsistent region selection criteria, and variable ways to quantify immune infiltration, all underline the urgent requirement to reach assay harmonization. In an effort to promote the Immunoscore in routine clinical settings, an international task force was initiated. This review represents a follow-up of the announcement of this initiative, and of the J Transl Med. editorial from January 2012. Immunophenotyping of tumors may provide crucial novel prognostic information. The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)
<> by Antonio Daponte( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial by Immacolata Capasso( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis by Corrado Caracò( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Dynamic coupling of 99mTc-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients by Silvana Del Vecchio( )

1 edition published in 2002 in English and held by 2 WorldCat member libraries worldwide

Lymph node fine needle Cytology in the staging and follow-up of Cutaneous Lymphomas by Elena Vigliar( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts by David Carbone( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th-1 December 1st, 2018, Naples, Italy) by Paolo A Ascierto( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Increased HOX C13 expression in metastatic melanoma progression by Monica Cantile( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Automatic discovery of image-based signatures for ipilimumab response prediction in malignant melanoma by Nathalie Harder( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Vinorelbine plus 3-weekly trastuzumab in metastatic breast cancer: a single-centre phase 2 trial by Ermelinda De Maio( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

Tumor biobanks in translational medicine by Gerardo Botti( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma by Luigi Fattore( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Assessment of germline and somatic alterations in main candidate genes among patients with multiple primary melanoma by Maria Colombino( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment by Paolo A Ascierto( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Breast systemic follicular lymphoma in a man: a case report by Elvira La Mantia( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

 
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Audience level: 0.97 (from 0.97 for AurkA inhi ... to 0.97 for AurkA inhi ...)

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Languages
English (22)