WorldCat Identities

Crook, Julia

Overview
Works: 8 works in 9 publications in 1 language and 17 library holdings
Roles: Contributor, Other
Classifications: R1, 617.5
Publication Timeline
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Most widely held works by Julia Crook
Can explicit convection improve modelled dust in summertime West Africa? by Alexander J Roberts( )

2 editions published in 2018 in English and held by 4 WorldCat member libraries worldwide

Computed tomography analysis of acetabular anteversion and abduction by Eric S Stem( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci by Mariet Allen( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Physical exercise and cognitive engagement outcomes for mild neurocognitive disorder: a group-randomized pilot trial by Liselotte De Wit( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations by Jannet Kocerha( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

In vivo silencing of alpha-synuclein using naked siRNA by Jada Lewis( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Late-onset Alzheimer disease risk variants mark brain regulatory loci( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: To investigate the top late-onset Alzheimer disease (LOAD) risk loci detected or confirmed by the International Genomics of Alzheimer's Project for association with brain gene expression levels to identify variants that influence Alzheimer disease (AD) risk through gene expression regulation. Methods: Expression levels from the cerebellum (CER) and temporal cortex (TCX) were obtained using Illumina whole-genome cDNA-mediated annealing, selection, extension, and ligation assay (WG-DASL) for ∼400 autopsied patients (∼200 with AD and ∼200 with non-AD pathologies). We tested 12 significant LOAD genome-wide association study (GWAS) index single nucleotide polymorphisms (SNPs) for cis association with levels of 34 genes within ±100 kb. We also evaluated brain levels of 14 LOAD GWAS candidate genes for association with 1, 899 cis -SNPs. Significant associations were validated in a subset of TCX samples using next-generation RNA sequencing (RNAseq). Results: We identified strong associations of brain CR1, HLA-DRB1, and PILRB levels with LOAD GWAS index SNPs. We also detected other strong cis- SNPs for LOAD candidate genes MEF2C, ZCWPW1, and SLC24A4 . MEF2C and SLC24A4, but not ZCWPW1 cis -SNPs, also associate with LOAD risk, independent of the index SNPs. The TCX expression associations could be validated with RNAseq for CR1, HLA-DRB1, ZCWPW1, and SLC24A4. Conclusions: Our results suggest that some LOAD GWAS variants mark brain regulatory loci, nominate genes under regulation by LOAD risk variants, and annotate these variants for their brain regulatory effects
 
Audience Level
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Audience Level
1
  Kids General Special  
Audience level: 0.96 (from 0.88 for Late-onset ... to 0.97 for Can explic ...)

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