WorldCat Identities

Nemoto, Tetsuhiro

Overview
Works: 6 works in 6 publications in 1 language and 10 library holdings
Roles: Contributor, Other
Publication Timeline
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Most widely held works by Tetsuhiro Nemoto
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1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model by Kai Zhang( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Synthesis of functionalized iodoalkenes using a multicomponent reaction triggered by electrophilic iodination of alkenyldiazoacetates( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Graphical abstract: Highlights: A novel iodoalkoxylation of alkenyl diazoacetates has been developed. This metal-free iodination reaction proceeds without the use of a catalyst. The methodology efficiently provides trisubstituted iodoalkene derivatives. The obtained vinyl iodides were applied to Suzuki-Miyaura coupling reactions. Abstract: Diazo compounds are frequently used as precursors of metal carbenoids and act as soft nucleophiles even without the use of metal catalysts. The resulting diazonium species may also be trapped by various nucleophiles. The introduction of an iodine functionality applicable for the coupling reaction into an alkenyl diazo compound, however, has not been reported. We developed iodoalkoxylation reactions of alkenyl diazoacetates using an electrophilic iodinating reagent and oxygen nucleophile. This catalyst-free multicomponent reaction proceeded regioselectively, furnishing trisubstituted vinyl iodides in 31%-71% yield. The synthesized iodoalkenes were converted into the corresponding olefins with various functionalities in good yield via Suzuki-Miyaura coupling reactions with arylboronic acids under palladium catalysis to demonstrate the synthetic utility of the developed reaction sequence
Binary additive effect of benzoic acid in ipso-Friedel-Crafts-type dearomatization of phenols using a chiral silver phosphate( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: We previously developed a chemoselective asymmetric phenol dearomatization using a silver catalyst and benzoic acid as an additive to enhance the reaction efficiency. The mechanistic role of the additive, however, remained unclear. Herein we describe detailed studies to elucidate the additive effect, which revealed that benzoic acid plays two supporting roles in the silver-catalyzed reaction. First, it promotes protonation of a silver enolate intermediate to improve the chemical yield of a spirolactam. Second, it dissociates a homochiral dimer of silver phosphate to generate a monomeric species. Graphical abstract
 
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