WorldCat Identities

Onohara, Takeshi

Overview
Works: 4 works in 4 publications in 1 language and 7 library holdings
Roles: Contributor
Publication Timeline
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Most widely held works by Takeshi Onohara
Debranching thoracic endovascular aortic repair for distal aortic arch aneurysm in elderly patients aged over 75 years old by Suguru Shiraya( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Smooth muscle cell sheet transplantation preserve cardiac function and minimize cardiac remodeling in a rat myocardial infarction model by Shingo Harada( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Tolvaptan can limit postoperative paroxysmal atrial fibrillation occurrence after open-heart surgery by Yoshinobu Nakamura( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Effect of tiopronin on excretion of homocysteine and its plasma exposure level in rats( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: When the biosynthesis of homocysteine (Hcy), an amino acid containing thiol, exceeds its elimination, plasma Hcy concentration increases and results in hyperhomocysteinemia (HHC). Most of the Hcy in plasma covalently binds to the cysteine residues of albumin by disulfide bonds. Meanwhile tiopronin (TP), a thiol-containing compound, is used for treatment of cysteinuria to decrease the amount of insoluble cystine in urine, by replacing a cysteine molecule in cystine with TP to form soluble TP-cysteine complexes. The present study investigated the effect of TP on the total (protein-unbound and protein-bound) Hcy concentration and the ratio of protein-unbound Hcy to total Hcy in plasma, and the urinary excretion of Hcy. Methionine was administered orally to rats to induce temporary hyperhomocysteinemia, and then TP was administered and the plasma and urine were collected. The amount of Hcy excreted in urine was higher but the plasma concentration of Hcy was lower in the TP group than in the control group until 3h after TP administration. In addition the ratio of protein-unbound Hcy in plasma tended to be increased by TP administration. These results demonstrated that TP enhanced the urinary excretion of Hcy, which might cause the decrease of its plasma concentration in rats
 
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Audience level: 0.96 (from 0.88 for Effect of ... to 0.97 for Debranchin ...)

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