WorldCat Identities

IDIBAPS

Overview
Works: 106 works in 117 publications in 3 languages and 118 library holdings
Roles: isb
Publication Timeline
.
Most widely held works by IDIBAPS
Memoria by Institut d'Investigacions Biomèdiques August Pi i Sunyer( )

in Catalan and Spanish and held by 4 WorldCat member libraries worldwide

Annual scientific report by IDIBAPS( )

in English and Spanish and held by 4 WorldCat member libraries worldwide

IDIBAPS : Institut d'Investigacions Biomèdiques August Pi i Sunyer by Institut d'Investigacions Biomèdiques August Pi i Sunyer( Book )

4 editions published in 2003 in 3 languages and held by 4 WorldCat member libraries worldwide

Mecanismos de protección del precondicionamiento isquémico en el trasplante hepático de injertos esteatósicos by Esther Carrasco Chaumel( Book )

2 editions published between 2005 and 2006 in Spanish and held by 2 WorldCat member libraries worldwide

Modelo experimental de endocarditis infecciosa( Visual )

2 editions published in 2002 in Spanish and held by 2 WorldCat member libraries worldwide

Model experimental d'endocarditis infecciosa( Visual )

2 editions published in 2002 in Catalan and held by 2 WorldCat member libraries worldwide

KATP channel blockade instructs microglia to foster brain repair and neurogenesis after stroke by Fco. Javier Ortega González( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Tratamiento de la hepatitis crónica C antes y después del trasplante hepático (TH) y diagnóstico no invasivo de su recurrencia tras el TH by José Antonio Carrión Rodríguez( )

1 edition published in 2010 in Spanish and held by 1 WorldCat member library worldwide

Estudio de los tocotrienoles como inductores de muerte programada en las células estrelladas del páncreas by Mariana Rickmann Ashwell( )

1 edition published in 2010 in Spanish and held by 1 WorldCat member library worldwide

Efecto de la infección del citomegalovirus sobre receptores SLAM en macrófagos murinos by Angela María Zarama Ortiz( Book )

1 edition published in 2014 in Spanish and held by 1 WorldCat member library worldwide

Los receptores de la familia SLAM se encuentran expresados diferencialmente en la superficie de los leucocitos y juegan un papel importante en la inmunidad innata y adaptativa. En este trabajo se demuestra que el citomegalovirus (CMV) murino reduce específicamente la expresión de determinados miembros SLAM en la superficie de los macrófagos infectados. Mediante el escrutinio de un panel de mutantes de deleción del CMV murino se ha identificado m154 como el producto viral que modula la expresión del receptor SLAM CD48, el cual constituye el ligando de alta afinidad de CD244, una molécula involucrada en la regulación funcional de las células NK y T citotóxicas. Se muestra que m154 es una proteína tipo mucina, que se expresa con una cinética temprana y se localiza en la superficie de la célula infectada. La proteína viral actúa a través de un mecanismo que implica la degradación de CD48, siendo capaz de interferir con la respuesta citotóxica de las células NK desencadenada por la infección de los macrófagos por el CMV murino. Finalmente, demostramos en el modelo murino, que m154 le proporciona al virus protección in vivo frente al ataque de las células NK. Estos hallazgos contribuyen a un mejor entendimiento de la patogénesis del CMV y proveen un nuevo ejemplo de evasión de la inmunidad innata del huésped desarrollado por CMV
Caracterització de la infecció pel virus de l'hepatitis C en el marc del trasplantament hepàtic estudi de l'expressió dels receptors d'entrada i dels antigens virals by Laura Mensa Garrigosa( Book )

1 edition published in 2014 in Catalan and held by 1 WorldCat member library worldwide

La present tesi doctoral està centrada en l'estudi de l'expressió dels receptors d'entrada del virus de l'hepatitis C (VHC) i la detecció dels antígens virals en mostres de fetge parafinades de pacients sotmesos a un trasplantament hepàtic (TH). La primera part de l'estudi està basada en la caracterització i anàlisi, mitjançant tècniques d'immunofluorescència i microscòpia confocal, de l'expressió dels receptors d'entrada claudina-1 (CLDN1), ocludina (OCLN) i SRB1. També s'ha dut a terme l'estudi de la cinètica viral precoç amb mostres de sèrum obtingudes abans i després del TH. Els resultats obtinguts mostren que la localització de les proteïnes CLDN1 i OCLN resta inalterable al pol apical de la cèl.lula, on colocalitzen fortament independentment de la fase de la infecció. Paral.lelament s'observa una correlació significativa entre: 1. els nivells d'SRB1 en el moment de la reperfusió del nou òrgan i la disminució de la càrrega viral (CV) a les 24h després del TH, el que suggereix l'entrada massiva del virus a l'empelt i 2. els nivells de CLDN1 i OCLN i l'increment de la CV a la setmana després del TH, el que és indicatiu de l'elevada capacitat d'adaptació i replicació del VHC. En la segona part del treball s'analitza l'expressió dels antigens virals core i NS5A i es determina la colocalització entre abdues proteïnes i la seva distribució relativa versus les estructures cel.lulars denominades gotes lipídiques. Els resultats mostren que en un 75% de les biòpsies de fase aguda analitzades és possible detectar l'antigen core, l'expressió del qual es limita als hepatòcits. El marcatge és citoplasmàtic i granular, amb diferents graus d'intensitat. El patró de distribució de la tinció és difús, amb certa tendència a concentrar-se a les zones periportals. Existeix una correlació significativa entre el percentatge de cèl.lules core positives i: 1. l'activitat inflamatòria al lobulet i 2. els nivells de transaminasas ALT i AST. La detecció de l'expressió de la proteïna core s'associa de forma significativa amb la CV i existeix colocalització entre NS5A, core i adipofil.lina (proteïna constitutiva de les gotes lipídiques). Aquesta localització es dóna en forma d'estructures circulars, essent NS5A la proteïna que es situa majoritàriament a la part més perifèrica. Els resultats demostren per primera vegada in vivo la importància de les gotes lipídiques en la replicació i l'assamblatge del VHC
Mecanismos de protección en el precondicionamiento intestinal : papel del óxido nítrico y de los radicales libres del oxígeno by Anna Sola Martínez( )

1 edition published in 2000 in Spanish and held by 1 WorldCat member library worldwide

Caracterització del paper de la proteïna associada a la pancreatitis en la modulació de la resposta inflamatòria by Montse Ferrés Masó( )

1 edition published in 2009 in Catalan and held by 1 WorldCat member library worldwide

SOX11 transcription factor functional analysis in aggressive MCL by Maria Carmela Vegliante( Book )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified as a very specific biomarker for MCL. SOX11 is constantly overexpressed in virtually all aggressive MCLs, and at lower levels in a subgroup of Burkitt lymphoma and acute lymphoblastic leukemia but not in other lymphoid neoplasms. SOX11 was found exclusively overexpressed in conventional MCL and totally absent in normal lymphoid cells or in MCL patients with indolent clinical course and prolonged survival. Although SOX11 function and potential target genes in lymphoid cells are poorly known, the highly specific expression in aggressive MCL suggests that it may be an important element in the development and progression of this tumor. Two publications resulted from our studies and compose this thesis. In paper I, we have studied the molecular mechanisms leading to the aberrant expression of SOX11 in aggressive MCL. MCL is one of the lymphoid neoplasms with highest number of genetic aberrations but none involving the SOX11 genomic region at chromosome 2p25. As no chromosomal changes affecting SOX11 locus were identified in MCL, we hypothesized that epigenetic events could lead to SOX11 aberrant overexpression. We performed a comprehensive SOX11 gene expression and epigenetic studies. We observed that SOX11 expression was associated with unmehtylated DNA and presence of activating histone marks (H3K9/14Ac and H3K4me3) in embryonic stem cells and some aggressive B-cell neoplasms, including MCL. Conversely, the loss of SOX11 expression in adult stem cells, normal hematopoietic cells and other lymphoid neoplasms was associated with the presence of silencing histone marks H3K9me2 and H3K27me3 with or without simultaneous DNA methylation. We concluded that the pathogenic role of SOX11 is associated with its de novo expression in some aggressive lymphoid malignancies, which is mediated by a shift from inactivating to activating histone modifications. In paper II, we have focused on uncovering putative biological functions of SOX11 in aggressive MCL. Using chromatin immunoprecipitation microarray analysis combined with gene expression profiling upon SOX11 knockdown, we identified target genes and transcriptional programs regulated by SOX11 including the block of mature B-cell differentiation, modulation of cell cycle, apoptosis, and stem cell development. PAX5 stood out as one of the major SOX11 direct target genes. SOX11 silencing downregulates PAX5, induces BLIMP1 expression, and promotes the shift from a mature B-cell into the initial plasmacytic differentiation phenotype in both MCL primary tumor cells and an in vitro model. Our results suggested that SOX11 contributes to tumor development by altering the terminal B-cell differentiation program of MCL cells. Moreover, we have demonstrated the tumorigenic ability of SOX11 in vivo, using a xenotransplant model of MCL in CB17-SCID mice. The significant reduction on tumor growth of the SOX11-silenced cells compared to the growth of control MCL cells in the xenograft experiments highlighted the implication of SOX11 expression in the aggressive behavior of this lymphoma. Overall our results demonstrated that SOX11 can act as oncogene in MCL
Cell-type specific microRNA regulation of adenovirus for selective treatment of pancreatic ductal adenocarcicoma by Xavier Bofill i de Ros( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Plasticity of dust cells in the embryonic and postnatal pancreas by Myriam Solar Abboud( )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

Neuroimaging correlates of cognitive functioning in cerebrovascular disease by Marina Fernández-Andújar( Book )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Cerebrovascular diseases (CD) are the third most common cause of death and the leading cause of disability in adults in developed countries (Carmichael, 2012; World Health Organization, 2004). Specifically, ischemic stroke and white matter lesions (WML) often result in multiple neurological, cognitive impairment and behavioral and emotional disorders (Gorelick et al., 2011; Troncoso et al., 2008). Strokes are responsible for damage in the core of the ischemic lesion but may also cause alterations in remote areas from the primary ischemic lesion. The thalamus is a key structure in the cortico-subcortical circuits (Alexander et al., 1986; Byne et al., 2009) and is involved in multiple cognitive functions (Herrero et al., 2002; Sherman, 2005) especially in functions executive, one of the most affected cognitive domains after suffering a stroke. Although it is known that the cortico- subcortical circuits are involved in cognitive functions, to date their neuroimage correlates are unknown. The overall objective of this thesis was to study the effects of a disruption in the cortico-subcortical circuits, due to a direct or remote damage, in executive functions. For the study of remote thalamic abnormalities we use the technique of diffusion tensor image (DTI) for both ischemic stroke and WML. Moreover, due to attention and cognitive inhibition are one of the most important functions of executive domain, we studied the relationship between a specific white matter (WM) tract -called Front aslant Tract (FAT)- and these functions. The study results showed that remote thalamic microstructural abnormalities secondary to a cerebrovascular lesion can occur in both ipsilateral and contralateral thalamus, in healthy subjects with WML and in patients with cerebral ischemic stroke. These thalamic abnormalities may be related to a disruption in the cortico-subcortical circuits associated with executive dysfunction. In addition, the right FAT is involved in attention and response inhibition functions in community-dwelling subjects and participants with ischemic stroke. In conclusion, the results obtained in this thesis suggest that stroke can affect the cortico-subcortical circuits through thalamic microstructural abnormalities and these could be related to cognitive dysfunction. Finally, the novel technique of DTI can play an important role in understanding the cognitive functioning in both ischemic stroke and WML
Broadly neutralizing antibody responses against HIV-1 : characterization and design of new immunogens by Carolina Ferreira( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.96 (from 0.93 for Memoria / ... to 0.98 for IDIBAPS : ...)

Alternative Names
August Pi i Sunyer Institute of Biomedical Research

IDIBAPS

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Institut d'Investigacions Biomèdiques August Pi i Sunyer research institute in Catalonia

Instituto de Investigaciones Biomedicas August Pi i Sunyer

Instituto de Investigacións Biomédicas August Pi i Sunyer

Languages
Spanish (14)

English (10)

Catalan (7)