WorldCat Identities

Chiquet, Christophe (1964-....).

Works: 43 works in 54 publications in 2 languages and 224 library holdings
Genres: Case studies 
Roles: Publishing director, Author of introduction, Thesis advisor, Other, Opponent, Author
Publication Timeline
Most widely held works by Christophe Chiquet
Ophtalmologie by Collège des ophtalmologistes universitaires de France( Book )

6 editions published between 2012 and 2021 in French and English and held by 109 WorldCat member libraries worldwide

En parfaite conformité avec le nouveau programme de DFASM (Diplôme de formation approfondie en sciences médicales, BO du 16 mai 2013), cet ouvrage aborde les connaissances fondamentales en ophtalmologie. Il comprend deux parties : une partie Connaissances divisée en 23 chapitres commençant systématiquement par un rappel des objectifs pédagogiques puis développant la thématique, étayée de points clés, de notions à retenir, de tableaux et de figures ; une partie Pratique qui propose 10 cas cliniques avec grilles de correction ainsi que 58 QCM, offrant un
L'ophtalmologie facile aux ECNi : fiches visuelles by Benoît Delaunay( Book )

2 editions published in 2017 in French and held by 50 WorldCat member libraries worldwide

Monitoring of visual field over six months after active ocular toxoplasmosis by Julie Blot( )

2 editions published between 2017 and 2019 in English and held by 4 WorldCat member libraries worldwide

Purpose: To prospectively report the perimetric defects during a six-month follow-up (FU) in patients with initially active ocular toxoplasmosis (OT). Methods: Twenty-four patients were studied, including 11 eyes with a chorioretinal toxoplasmosis proven with a positive aqueous humor sample and 13 eyes with a typical chorioretinal lesion biologically unproven. Kinetic perimetry with visual fields 24-2 were performed at baseline, first month and sixth month of FU and all parameters were noted. A composite clinical severity score was calculated from visual acuity (VA in LogMAR), severity of vitritis, chorioretinal lesion size, a localization of the lesion in zone 1, the presence of an initial macular or papillary edema and a long-time scarring. This permitted to have a relative cut-off level of severity. Nine eyes were considered like severe OT among the 24 included eyes. Results: Initial and final visual field parameters (MD and PSD) were strongly correlated in all OT. During FU, only FT was correlated with VA. MD initial predictive value of severity was 0.739 according to ROC curve. At baseline, at the first month and at the sixth month, none parameter showed a significant difference between severe and non-severe OT, whereas each parameter considered during complete FU related a significant difference (MD, p=0.0118; PSD, p=0.05; VFI, p=0.016 and FT, p=0.021). Conclusion: Visual field parameters better contextualized the chorioretinal destruction related to toxoplasmosis lesion and the functional repercussions than visual acuity alone. Interestingly, MD could be a discriminating factor of severity in active OT, and each visual field parameter follow-up could be a support to manage patients with active OT. Our study suggested an original clinical score of severity in this most frequent form of posterior uveitis in the world
L'aspirine n'est pas un facteur de risque de complications hémorragiques pendant et après une première chirurgie de décollement de rétine rhegmatogène by Eva Zaratzian Brillat( )

2 editions published in 2011 in English and held by 3 WorldCat member libraries worldwide

Objective: To evaluate the hemorrhagic risk of treatment by acetylsalicylic acid, during the management of primary rhegmatogenous retinal detachment (RD). Design: case-control study (according to presence of perioperative bleeding complications). Participants: 322 patients (322 eyes) from a prospective cohort of 835 patients with primary rhegmatogenous RD operated on between 2004 and 2007. Methods: After exclusion of patients with RD secondary to trauma, subjects with a history of vitreoretinal surgery, diabetic retinopathy, aphakia or taking clopidogrel and/or a vitamin K antagonist, 74 patients were included in the hemorrhagic group and patients without hemorrhagic complications were randomly selected in order to reach a 1:3 case: control population. Univariate and multivariate analyses were performed to identify risk factors of perioperative bleeding. Main outcome measures: Occurrence of hemorrhagic complications such as hyphema and intravitreal, subretinal and suprachoroidal hemorrhage. Prognostic factors included final visual acuity (LogMAR) and the single-operation attachement rate. Results: Univariate analysis showed that the presence of initial vitreous hemorrhage, size of breaks, number of breaks, pars plana vitrectomy (PPV) and the number of cryotherapy impacts were significantly associated with perioperative bleeding. Independent risk factors of perioperative hemorrhage were the number of cryotherapy sessions (odds ratio =1.12 [1.06; 1.20], 95% CI), transscleral drainage (OR =4.22 [1.62; 10.98]), and PPV (OR =3.39 [1.36; 8.47]). The occurrence of bleeding complications was associated with a lower single-operation anatomical success rate. There was also a trend toward an association between bleeding complications, the total number of RD recurrences, and final visual acuity. Conclusion: Aspirin was not an independent risk factor of hemorrhagic complications during and after surgery of primary rhegmatogenous RD. The bleeding risk is instead associated with surgical factors such as PPV, cryotherapy, and subretinal fluid drainage
Étude comparative de la vitrectomie transconjonctivale sans suture 23 gauge versus 20 gauge dans la chirurgie du décollement de rétine by Magali Albrieux( )

2 editions published between 2010 and 2011 in English and held by 3 WorldCat member libraries worldwide

Introduction: comparer les résultats de la vitrectomie transconjonctivale 23G versus 20G dans la chirurgie des décollements de rétine rhegmatogènes. Matériels et méthodes: cette étude prospective inclut 35 patients consécutifs opérés par vitrectomie transconjonctivale 23G appariés avec 35 patients opérés par vitrectomie 20G, en fonction des critères pré-opératoires suivants : meilleure acuité visuelle corrigée, longueur axiale, statuts cristallinien et maculaire, localisation et nombre de déchirures, stade de prolifération vitréo-rétinienne et durée du voile noir. Tous les patients ont bénéficié d'une vitrectomie, cryothérapie et échange fluide-gaz. Résultats: La majorité des patients étaient pseudophaques (77,1%). La macula était à plat dans 37 % des cas et la prolifération vitréo-rétinienne était inférieure au stade C. Tous les patients ont eu un suivi postopératoire minimum de six mois. Le temps opératoire moyen et le taux de complications per-opératoires (11.4%) étaient similaires dans les deux groupes. Le taux de réapplication en une intervention et le taux de succès anatomique final étaient similaires dans les deux groupes, 77% et 97% respectivement. L'acuité visuelle moyenne s'est améliorée dans les deux groupes de 1.2 ± 0.9 logMAR en préopératoire à 0.4 ± 0.4 logMAR à la visite finale. Des sutures sclérales ou conjonctivales ont été nécessaires dans 5% et 51% des cas respectivement. Aucun cas de décollement choroïdien ou d'endophtalmie n'a été observé. Conclusion: La vitrectomie transconjonctivale 23G est aussi sûre et efficace que le système 20G pour la prise en charge des DR rhegmatogènes non compliqués
Optic-nerve-head blood-flow response to increase in arterial blood pressure in humans by Tiffany Lacharme( )

2 editions published in 2011 in English and held by 3 WorldCat member libraries worldwide

Purpose. Autoregulation in ocular tissues ensures constant blood flow despite variations in ocular perfusion pressure and may be impaired in ocular diseases. The purpose of this study was to investigate the effect of increased blood pressure (BP) and ocular perfusion pressure (OPP) during isometric exercise on optic-nerve-head blood flow (ONH-BF). Methods. In 21 healthy subjects, aged 18-40 years, BP was measured using a Nexfin™ pneumatic transcutaneous sensor and blood flow was measured using laser Doppler flowmetry (LDF). OPP was defined as (0.74 × mean BP) - intraocular pressure. Handgripping consisted of static contraction of the finger flexors at 30% maximum contraction force using a hand dynamometer for 2 min. Results. Data were analyzed in 15 healthy subjects, exhibiting a homogeneous response of BP to handgripping (linear regression of BP versus time). A large increase, up to 50%, in OPP during exercise was not associated with a proportional increase in ONH-BF; vascular resistance increased about 30%. The blood flow-pressure relationship showed blood flow significantly increased by approximately 30%, mainly due to the rise in velocity. Conclusion. These new data strongly support the notion of autoregulation in ocular blood flow, protecting the eye from overperfusion. However, the increase in OPP is not completely counterbalanced despite the regular increase in vascular resistance. This blood flow regulation is possibly due to vasoconstriction, taking place outside of the sampled volume, probably in the arterioles proximal to the capillary bed of the neuroretinal rim. In the future, real-time measurements of vascular resistance during handgripping could be investigated in glaucoma patients
Specific PCR and quantitative real time PCR in ocular samples from acute and delayed-onset post operative endophthalmitis by Julie Kosacki( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Objective: To evaluate the contribution of specific PCR targeting S. aureus and S. pneumonia for the identification of these species and the quantitative PCR for endophthalmitis due to S. epidermidis in ocular samples from patients with acute or delayed-onset post-operative endophthalmitis. Methods: 153 consecutive patients presenting with acute or delayed-onset postoperative endophthalmitis were included in three university hospitals between 2008 and 2016. A total of 284 ocular samples were obtained from aqueous humor (AH) or vitreous fluids (VF): 151 samples at admission and 133 after one intravitreal injection of antibiotics. Microbiological techniques include bacterial culture after inoculation into pediatric blood culture bottle, 16S PCR, real-time PCR assays for the detection of specific sequence regions of S. aureus femA gene and S. pneumoniae lytA gene. Quantitative real-time PCR assay targeting the tuf gene of Staphylococcus spp was used for 25 patients infected with S. epidermidis. Results: At the time of admission; the detection rate was not significantly different between PCR and cultures (38% versus 30% in AH samples; 66% versus 63% in vitreous fluid, p=0.6). ln contrast, after one intravitreous injection of antibiotics, the identification rate was higher using PCR (62%) in VF than using culture (48%, p=0.05). Bacteria was identified in 70% with a predominance of Gram-positive bacteria (93%). Specific PCR targeting S. aureus and S. pneumonia were notable to make additional diagnosis. Quantitative PCR performed before and after treatment found no significant changes in bacterial load after one intravitreal injection (51803 ±47161 DNA copies/ml at admission versus 95737 ±147431 after antibiotic treatment, p=0.6). Conclusion: Identification rate was better in vitreous fluid than in aqueous humor. 16s PCR is more effective than cultures in detecting bacteria in vitreous samples after intravitreal administration of antibiotics. PCR targeting S. aureus and S. pneumonia were specific but, with the low frequency of endophthalmitis due to these virulent bacteria, sensitivity was not determined. Real-time quantitative PCR targeting the tuf gene of Staphylococcus spp showed high level of bacterial load and no change of DNA copies after one intravitreal injection of antibiotics
Antithrombotics prevalence in a vitreoretinal surgery cohort of patients by Mathilde Gallice( )

1 edition published in 2014 in French and held by 2 WorldCat member libraries worldwide

Context: Elderly population taking antithrombotic therapy is growing. Patients benefiting of vitreoretinal surgery is also old. However no consensus exist regarding the management of antithrombotics in vitreoretinal surgery. Objective: To determine the prevalence of antiplatelet agents and anticoagulant therapy in a French vitreoretinal surgery cohort. Our secondary objective was to identify the prevalence of the new antiplatelet and new oral anticoagulant herapy (AOD) in our population. Design and setting: Any patient benefiting of a vitreoretinal surgery was included using a standardised questionnaire. Thus, 1313 patients are analysed in a prospective multicentric manner from February 2012 to November 2013. Main outcome measures Prevalence of an antiplatelet agent (APA) and/or anticoagulant therapy (AC). Results: On a period of 23 months, 235 patients were treated by at least one APA including 3 treated by prasugrel. 87 patients were taking AC including 6 under rivaroxaban, 3 under pradaxa, and 1 under fondaparinux. Conclusions: From the literature findings and based on an a risk of 0.05 and a risk of 0.80 the estimated number of subjects to show an incidence reduction of haemorrhagic events of 50% is 12720 per group concerning APA and 1239 patients per group regarding AC
Diagnostic bactériologique précoce des endophtalmies aiguës post-opératoires par spectrométrie de masse MALDI-TOF by Adriane Mailhac( )

1 edition published in 2016 in French and held by 2 WorldCat member libraries worldwide

L'endophtalmie aiguë post-opératoire est une complication infectieuse bactérienne sévère. Les principaux facteurs pronostiques sont la virulence de la bactérie en cause, la rapidité du diagnostic, et l'instauration d'un traitement adapté. Le diagnostic microbiologique est basé sur la détection des bactéries dans les prélèvements intraoculaires, par culture ou PCR. La spectrométrie de masse (SM) MALDI-TOF est actuellement utilisée pour l'identification rapide des bactéries isolées en culture, et est en cours de validation pour l'identification directe sur fluide biologique. L'objectif de mon travail était de développer un protocole de diagnostic bactériologique rapide des endophtalmies par SM. Nous avons d'abord évalué la possibilité d'analyser par SM des vitrés infectés in vitro (inoculum de 0,5 et O,125 McFarland (McF)) déposés sur cible classique ou nanoporeuse. Nous n'avons pas observé de différence significative entre les 2 cibles avec la banque de données Bruker Daltonics (p=0,8 pour 0,5 McF; p=0,7 pour 0,125 McF) ou la banque spécifique de support (p=0,12 pour 0,5 McF et p=0,23 pour 0,125 McF). Nous avons ensuite opté pour l'ensemencement des vitrés infectés en flacons d'hémocultures. Un protocole d'extraction long ou court était appliqué au surnageant des hémocultures positives avant analyse par SM. Ce protocole obtenait un taux d'identification satisfaisant (72% protocole court SDS, 83% protocole court eau, 92% protocole long SDS, 96% pour le protocole long eau), meilleure avec une extraction longue (p<0.0001). Ce travail a permis de développer un protocole de diagnostic rapide des endophtalmies par SM, permettant de réduire le délai diagnostique de 24H
Autofluorecence dans la choriorétinopathie de Birdshot by Rachel Semecas( )

1 edition published in 2016 in English and held by 2 WorldCat member libraries worldwide

Purpose: To characterize and correlate the different patterns of fundus autofluorescence (FAF) in patients with Birdshot chorioretinopathy (BSCR), with functional and anatomical parameters. Methods: 21 BSCR patients were prospectively studied in 2013 and 2014. Each patient underwent visual acuity (VA) and visual field (SITA standard 30.2) testing as well as fluorescein and indocyanine green angiography, spectral-domain optical coherence tomography (SD-OCT) B scan, and enhanced depth imaging (EDI), and fundus autofluorescence (FAF) imaging. The disease was classified as active, chronic, or quiescent. Results: The patients' mean age was 60.3±9.2 years and 60% were female. Disease duration was 5.7±3.7 years. Autofluorescence imaging showed punctiform hyper-FAF spots in 23 out of the 29 eyes (79%), which was significantly associated with a larger visual field mean defect ( -7±7 versus -3±2 dB, p=0.04). Hypo-FAF was defined as peripapillary (n=25; 86.2%), macular (n=10; 34.5%), lichenoid (n=17; 58.6%), and/or diffuse (n=13; 44.8%). Lichenoid hypo-FAF was significantly associated with worse VA (0.18±0.24 vs 0.05±0.07 LogMAR, p=0.04). Macular hypo-FAF was associated with a history of macular edema (62.5%; p=0.06). Diffuse hypo-FAF was observed more frequently (p=0.01) in chronic disease (66.7%) than in active (0%) or quiescent disease (27.3%). Conclusion: Autofluorescence analysis in BRSC patients contributes to evaluating disease activity and could be useful to guide follow-up and treatment
Impact de l'hypoxie intermittente chronique sur la rétine et le nerf optique du rat : aspects vasculaire et inflammatoire. by Marielle Mentek( )

1 edition published in 2015 in French and held by 2 WorldCat member libraries worldwide

Le syndrome d'apnées obstructives du sommeil (SAOS) est associé à la survenue de neuropathies optiques, en particulier la neuropathie optique ischémique antérieure aigue non artéritique (NOIAA-NA). Parmi les mécanismes d'apparition de cette neuropathie et potentiellement associés au SAOS, la dysrégulation et l'inflammation vasculaires pourraient jouer un rôle. Il n'existe aucune donnée dans la littérature sur l'effet de l'hypoxie intermittente (HI) chronique sur la fonction vasculaire de l'œil.Le but de ce travail était de développer des techniques d'évaluation de la fonction vasculaire oculaire chez le rat et de les appliquer à l'étude des conséquences vasculaires oculaires de l'HI. Ainsi, deux approches complémentaires ont été développées : 1) un prototype de fluxmètre laser Doppler (LDF) adapté au rongeur pour l'évaluation in vivo de la perfusion sanguine rétinienne et de la tête du nerf optique (TNO) et 2) le modèle d'étude de l'artère ophtalmique (AO) du rat par myographie vasculaire, in vitro.La mise au point du LDF chez le rat sain a permis de valider la pertinence du signal provenant des artères rétiniennes. A l'inverse, nos données invalident l'intérêt de la mesure au niveau de la TNO. En réponse à l'inhalation d'oxygène pur, nous observons une diminution de 17,0 ± 13,7 % de la vélocité artérielle rétinienne (VelART). Nous n'observons pas de variation significative de VelART lors d'injection intra-carotidienne d'endothéline 1 (ET-1) malgré une forte vasoconstriction des vaisseaux rétiniens. Les perspectives consistent à associer une caméra de haute résolution à un système bidirectionnel de LDF. L'étude de la réactivité de l'AO par myographie chez le rat soumis à 14 jours d'HI a mis en évidence une augmentation de la contraction à l'ET-1, associée à une augmentation de la réponse médiée par les récepteurs de type A (ETRA)et à une surexpression des ETRA au sein de l'AO. La relaxation NO-dépendante était diminuée chez le rat HI, et associée à un effet prédominant des produits vasoconstricteurs du cytochrome P450. Ces réponses étaient associées à une augmentation de la présence d'anions superoxyde dans la paroi de l'AO. Des études complémentaires sont nécessaires pour explorer les mécanismes à l'origine des ces altérations vasculaires, en particulier le rôle du stress oxydant
Choroidal blood flow regulation after posture change or isometric exercise in men with obstructive sleep apnea syndrome by Hafide Khayi( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Study objectives: We hypothesized that choroidal vascular reactivity secondary to isometric exercise and change in body position, dependent of the autonomic nervous system, was altered in patients with obstructive sleep apnea (OSA) syndrome. Methods: Healthy men were matched 1:1 for body mass index, sex, and age with patients with newly diagnosed OSA without comorbidities, for the exercise (n=14) and change of posture (n=15) experiments. All subjects underwent sleep studies, 24-hour blood pressure monitoring, arterial stiffness measurements, and cardiac and carotid echography. Choroidal microvascular reactivity were assessed by laser Doppler flowmetry, allowing the real time measurement of subfoveal choroidal blood velocity, volume, and flow. Results: Patients with OSA and control subjects exhibited a stability of blood flow during ocular pressure perfusion (OPP) increase and a similar linear relationship between vascular resistance and the OPP changes (in OSA subjects: y=8.5017*0.8303x and healthy subjects: y=20.7742* 0.6744x, p=0.0003). From sitting to supine position, a significant decrease (p<0.001) of MAP in the two groups (10.9% in OSA, 13.4% in healthy subjects) and a significant increase of IOP in the OSA group (p=0.02) were noted. Choroidal vasoreactivities to exercise and posture change were unchanged after 6 to 9 months of CPAP treatment. Conclusion: This study showed unimpaired choroidal vascular reactivity to isometric exercise and posture change in otherwise healthy men with OSA. The regulation of ocular blood flow, which partially depends on the ortho- and parasympathetic systems does not seem to be altered in the early course of OSA
Comparison between multifocal ERG and C-Scan SD-OCT ("en face" OCT) in patients with a suspicion of antimalarial retinal toxicity: preliminary results by Carl Arndt( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Étude comparative prospective des décollements de rétine rhegmatogènes chez les patients myopes forts, phaques versus pseudophaques by Diane Bernheim( )

1 edition published in 2010 in French and held by 2 WorldCat member libraries worldwide

The aim of this study is to compare anatomic and functional results of primary rhegmatogenous retinal detachment (RD) in high myopic eyes according to the lens status. From the database of 835 patients prospectively studied, 191 patients with high myopia were included (151 phakic and 40 pseudophakic eyes) and assessed for a minimal 6 months follow-up examination in this multicentric study. Each patient underwent a detailed preoperative evaluation including symptom duration, best corrected visual acuity (logMAR), intraocular pressure, lens status, fundus examination, and axial length. Surgery (pars plana vitrectomy (PPV) or scleral buckling (SB)) was left to the surgeon choice. Baseline and follow-up data were recorded at presentation, 1 and 6 months or more. The main endpoints were the primary reattachment rate at the 6-month visit; the final anatomical success rate, the postoperative VA (>20/40) and intra- and postoperative complications. The analysis showed 96% primary reattachment, and 54% (single surgery) or 44% (multi-surgery) visual acuity equal to or better than ≥20/40. Pseudophakic eyes differed from phakic eyes by age (older: 60.8±10.4 vs 49.9±12.3, p<0.001), smaller pupil dilation (8.0±1.5 mm vs 8.5±1.2 mm, p=0.02), more frequent PPV (80% vs 28.5%, p<0.001) and an higher rate of primary reattachment (92.5% vs 80.7%, p =0.05). This prospective study showed similar baseline RD characteristics for high myopic phakic or pseudophakic eyes, and a primary reattachment rate higher for pseudophakic eyes. After single or multi-surgery the functional prognosis was the same in the two groups and close to the published results in emmetropic eyes. Despite its anatomic particularities and morbidity risks factors, high operated myopic eyes developed few complications
Ocular manifestations of syphilis: recent cases over a 2.5-year period by Cindy Puech( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Prise en charge thérapeutique de la tuberculose oculaire présumée by Sabine Kouprianoff( )

2 editions published between 2007 and 2013 in French and held by 2 WorldCat member libraries worldwide

Uveitis secondary to tuberculosis is a rare event. The prevalence of tuberculosis is low in Western Europe and its microbiological identification is difficult. The clinical records of 13 patients with suspected tuberculosis uveitis referred to the Ophthalmology Department of Grenoble University, between 2002 and 2006, were retrospectively analysed. The clinical features of ocular inflammation were: bilateral panuveitis, posterior uveitis, Eales's disease, episcleritis and pars planitis. Patients received a specific antituberculosis treatment (with or without associated corticosteroid therapy). In presumed oculmar tuberculosis, antituberculosis treatment was useful to control intraocular inflammation in 91% of our patients
Visual field defects of the contralateral eye of non-arteritic ischemic anterior optic neuropathy: are they related to sleep apnea? by Florent Aptel( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

<> by Pierre-Raphaël Rothschild( )

1 edition published in 2015 in French and held by 2 WorldCat member libraries worldwide

Choroidal Thickness in Birdshot Retinochoroiditis Over a 2-Year Period by Raimondo Forte( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

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English (17)

French (14)