WorldCat Identities

Bouchard, Luigi

Overview
Works: 13 works in 17 publications in 2 languages and 28 library holdings
Roles: Contributor, Author, Other
Publication Timeline
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Most widely held works by Luigi Bouchard
<> by Sandra Côté( )

2 editions published in 2016 in English and held by 4 WorldCat member libraries worldwide

Étude moléculaire et enzymatique du 3-hydroxy-3-méthylglutaryl-CoA synthase mitochondriale humaine et de sa déficience héréditaire by Luigi Bouchard( Book )

3 editions published between 1998 and 2000 in French and held by 3 WorldCat member libraries worldwide

Étude de déterminants génétiques des comportements alimentaires et de l'obésité by Luigi Bouchard( Book )

2 editions published between 2004 and 2006 in French and held by 3 WorldCat member libraries worldwide

Tobacco smoke induces changes in IL-1 family in bronchial epithelial cells obtained from asthmatic individuals by Valérie Gagné-Ouellet( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

A founder mutation in the PEX6 gene is responsible for increased incidence of Zellweger syndrome in a French Canadian population by Sébastien Lévesque( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age by Simon Kebede Merid( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

MicroRNAs in Pregnancy and Gestational Diabetes Mellitus: Emerging Role in Maternal Metabolic Regulation by Cédrik Poirier( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men by Simon-Pierre Guay( )

1 edition published in 2014 in English and held by 2 WorldCat member libraries worldwide

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight by Leanne K Küpers( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

An analytic approach for interpretable predictive models in high-dimensional data in the presence of interactions with exposures( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

ABSTRACT: Predicting a phenotype and understanding which variables improve that prediction are two very challenging and overlapping problems in the analysis of high-dimensional (HD) data such as those arising from genomic and brain imaging studies. It is often believed that the number of truly important predictors is small relative to the total number of variables, making computational approaches to variable selection and dimension reduction extremely important. To reduce dimensionality, commonly used two-step methods first cluster the data in some way, and build models using cluster summaries to predict the phenotype. It is known that important exposure variables can alter correlation patterns between clusters of HD variables, that is, alter network properties of the variables. However, it is not well understood whether such altered clustering is informative in prediction. Here, assuming there is a binary exposure with such network-altering effects, we explore whether the use of exposure-dependent clustering relationships in dimension reduction can improve predictive modeling in a two-step framework. Hence, we propose a modeling framework called ECLUST to test this hypothesis, and evaluate its performance through extensive simulations. With ECLUST, we found improved prediction and variable selection performance compared to methods that do not consider the environment in the clustering step, or to methods that use the original data as features. We further illustrate this modeling framework through the analysis of three data sets from very different fields, each with HD data, a binary exposure, and a phenotype of interest. Our method is available in the eclust CRAN package
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

 
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Audience level: 0.94 (from 0.84 for Étude mol ... to 0.97 for Étude mol ...)

WorldCat IdentitiesRelated Identities
Languages
English (12)

French (5)