WorldCat Identities

Altenburger, Rolf

Works: 26 works in 33 publications in 2 languages and 119 library holdings
Roles: Other, Author, dgs, Contributor
Publication Timeline
Most widely held works by Rolf Altenburger
Emission von Blütenduft im Tagesrhythmus by Rolf Altenburger( Book )

5 editions published in 1989 in German and held by 27 WorldCat member libraries worldwide

Studies on the interaction of chemicals with cellular efflux transporter proteins Danio rerio Abcb4 and Homo sapiens ABCB1 by Kathleen Burkhardt-Medicke( )

1 edition published in 2018 in English and held by 18 WorldCat member libraries worldwide

Thermal tolerance and cadmium susceptibility of amphipods endemic to Lake Baikal by Lena Jakob( )

1 edition published in 2016 in English and held by 16 WorldCat member libraries worldwide

Lake Baikal, amphipods, climate change, cadmium, thermal tolerance, thermal limitation, oxygen consumption, ventilation, metabolic enzymes, metal sensitive fraction, metabolic depression. - Lake Baikal is affected by global change and regional human activities. The effects of rising temperature and pollution on the unique endemic littoral amphipod fauna of Lake Baikal are unresolved yet. This thesis provides insights into physiological processes determining thermal tolerance and cadmium (Cd) susceptibility in two littoral amphipod species (Eulimnogammarus verrucosus and Eulimnogammarus cyaneus) compared to the related gammarid Gammarus lacustris, which is ubiquitously spread in the Holarctic. Thermal constraints on the oxygen supply system in E. verrucosus, E. cyaneus and G. lacustris may shape the upper temperature limits to the thermal habitats of the species, in line with the theories of allometry of thermal tolerance and systemic to molecular hierarchy of thermal tolerance. Lethal concentrations of Cd were much lower for E. cyaneus and G. lacustris than for E. verrucosus. However, E. verrucosus showed metabolic depression when exposed to Cd concentrations far below lethal ones. These findings underscore the necessity of water management strategies strictly avoiding chemical contamination of Lake Baikal waters
Zebrafish locomotor activity as a sensitive effect-based tool for the assessment of environmental chemicals and mixtures by David Leuthold( Book )

2 editions published in 2020 in English and held by 11 WorldCat member libraries worldwide

Chemical contamination poses a risk to the aquatic environment. Chemicals can affect the biological quality of surface waters, i.e. the composition of aquatic communities. The preservation or restoration of a good ecological status of surface water bodies requires the determination of the chemical status and the assessment of its effects on biological quality. Current regulatory assessments are restricted to single priority chemicals. This approach does not account for the entirety of ecologically relevant chemicals, transformation products, or the joint effects of chemical mixtures that are ubiquitously present in water bodies. Various toxicity tests are used to assess biological effects of environmental chemicals onaquatic organisms. However, acute toxicity tests, such as the fish embryo acute toxicity test (OECD test no. 236), lack sensitivity to detect sub-lethal chemical toxicity, particularly in the realm of chemicals that target the developing nervous system. Therefore, new approaches are required to quantify the effects of chemicals and mixtures on neurotransmission and neurodevelopment. Embryo-larval stages of zebrafish (Danio rerio) represent an excellent model system for the detection of chemical neurotoxicity, particularly during early development which represents one of the most vulnerable life stages to chemical exposure. The functionality of the zebrafish nervous system can be determined using automated behavior assays. However, key variables that influence chemical-dependent behavioral effects are not well characterized. Therefore, this thesis seeks to refine the execution, computational analyses, and applicability domain of an automated light-dark transition zebrafish behavior assay to ultimately delineate distinct behavioral responses following exposure to environmental chemicals and mixtures
Effect-based methods are key. The European Collaborative Project SOLUTIONS recommends integrating effect-based methods for diagnosis and monitoring of water quality by Werner Brack( )

2 editions published in 2019 in English and held by 4 WorldCat member libraries worldwide

Mixture effects in samples of multiple contaminants An inter-laboratory study with manifold bioassays by Rolf Altenburger( )

2 editions published in 2018 in English and held by 3 WorldCat member libraries worldwide

Abstract: Chemicals in the environment occur in mixtures rather than as individual entities. Environmental quality monitoring thus faces the challenge to comprehensively assess a multitude of contaminants and potential adverse effects. Effect-based methods have been suggested as complements to chemical analytical characterisation of complex pollution patterns. The regularly observed discrepancy between chemical and biological assessments of adverse effects due to contaminants in the field may be either due to unidentified contaminants or result from interactions of compounds in mixtures. Here, we present an interlaboratory study where individual compounds and their mixtures were investigated by extensive concentration-effect analysis using 19 different bioassays. The assay panel consisted of 5 whole organism assays measuring apical effects and 14 cell- and organism-based bioassays with more specific effect observations. Twelve organic water pollutants of diverse structure and unique known modes of action were studied individually and as mixtures mirroring exposure scenarios in freshwaters. We compared the observed mixture effects against component-based mixture effect predictions derived from additivity expectations (assumption of non-interaction). Most of the assays detected the mixture response of the active components as predicted even against a background of other inactive contaminants. When none of the mixture components showed any activity by themselves then the mixture also was without effects. The mixture effects observed using apical endpoints fell in the middle of a prediction window defined by the additivity predictions for concentration addition and independent action, reflecting well the diversity of the anticipated modes of action. In one case, an unexpectedly reduced solubility of one of the mixture components led to mixture responses that fell short of the predictions of both additivity mixture models. The majority of the specific cell- and organism-based endpoints produced mixture responses in agreement with the additivity expectation of concentration addition. Exceptionally, expected (additive) mixture response did not occur due to masking effects such as general toxicity from other compounds. Generally, deviations from an additivity expectation could be explained due to experimental factors, specific limitations of the effect endpoint or masking side effects such as cytotoxicity in in vitro assays. The majority of bioassays were able to quantitatively detect the predicted non-interactive, additive combined effect of the specifically bioactive compounds against a background of complex mixture of other chemicals in the sample. This supports the use of a combination of chemical and bioanalytical monitoring tools for the identification of chemicals that drive a specific mixture effect. Furthermore, we demonstrated that a panel of bioassays can provide a diverse profile of effect responses to a complex contaminated sample. This could be extended towards representing mixture adverse outcome pathways. Our findings support the ongoing development of bioanalytical tools for (i) compiling comprehensive effect-based batteries for water quality assessment, (ii) designing tailored surveillance methods to safeguard specific water uses, and (iii) devising strategies for effect-based diagnosis of complex contamination. Graphical abstract: Highlights: Multiple mixtures of water pollutants demonstrated combined effects across bioassays. Bioassays detected joint responses from active components against a background. Mixture effects were in agreement with an additivity assumption. Jointly, apical and receptor-based assays retrieved mixture components bioactivities
Antimicrobials in constructed wetlands can cause in planta dysbiosis by Muhammad Arslan( )

1 edition published in 2019 in English and held by 3 WorldCat member libraries worldwide

Biozönotisches Testverfahren (PICT-Konzept) Analyse von Schadstoff-induzierten Effekten in Gewässern mit autotrophen Aufwuchszönosen by Mechthild Schmitt-Jansen( )

1 edition published in 2004 in German and held by 2 WorldCat member libraries worldwide

Unravelling the chemical exposome in cohort studies routes explored and steps to become comprehensive by Sebastian Huhn( )

1 edition published in 2021 in English and held by 2 WorldCat member libraries worldwide

Let us empower the WFD to prevent risks of chemical pollution in European rivers and lakes by Werner Brack( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Improved component-based methods for mixture risk assessment are key to characterize complex chemical pollution in surface waters by Leo Posthuma( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Map and model--moving from observation to prediction in toxicogenomics by Andreas Schüttler( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Strengthen the European collaborative environmental research to meet European policy goals for achieving a sustainable, non-toxic environment by Werner Brack( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

A holistic approach is key to protect water quality and monitor, assess and manage chemical pollution of European surface waters by Leo Posthuma( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Computational material flow analysis for thousands of chemicals of emerging concern in European waters by Jos van Gils( )

1 edition published in 2020 in English and held by 2 WorldCat member libraries worldwide

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts by Sarah E Crawford( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Increase coherence, cooperation and cross-compliance of regulations on chemicals and water quality by John Munthe( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

Future water quality monitoring: improving the balance between exposure and toxicity assessments of real-world pollutant mixtures by Rolf Altenburger( )

1 edition published in 2019 in English and held by 2 WorldCat member libraries worldwide

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  Kids General Special  
Audience level: 0.94 (from 0.92 for Emission v ... to 0.97 for Emission v ...)

Alternative Names
Altenburger, R.

English (21)

German (6)